Novel QCM and SPR sensors based on molecular imprinting for highly sensitive and selective detection of 2,4-dichlorophenoxyacetic acid in apple samples

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dc.contributor.authorCakir, Oguz
dc.contributor.authorBakhshpour, Monireh
dc.contributor.authorYilmaz, Fatma
dc.contributor.authorBaysal, Zubeyde
dc.date.accessioned2024-04-24T16:15:40Z
dc.date.available2024-04-24T16:15:40Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study aims to develop molecularly imprinted based quartz crystal microbalance (QCM) and surface plasmon resonance (SPR) sensors for highly sensitive and selective detection of 2,4-dichlorophenoxyacetic acid (2,4-D) and to determine their accuracy and precision by liquid chromatography-tandem mass spectrometry (LC-MS/MS) as a reference technique. Here, we synthesized non-imprinted (NIP) and 2,4-D-imprinted (MIP) [ethylene glycol dimetacrylate-N-metacryloyl-(L)-tryptophan methyl ester-p(EGDMA-MATrp)] polymeric nanofilms by using molecular imprinting technique. MIP and NIP nanofilms were characterized by fourier transform infrared spectroscopy attenuated total reflectance (FTIR-ATR), atomic force microscope (AFM), contact angle and ellipsometer measurements. The molecular imprinting procedures were successfully carried out and it was found that the prepared polymeric surfaces were highly desirable for sensitive recognition by QCM and SPR sensors. Competitive experiments for the sensors revealed that MW nanofilms were found to show more sensitivity and selectivity than NIP ones. The sensor responses have a good linear relationship with 2,4-D concentrations in the range of 0.23-8.0 nM with a limit of detection at 20.17 ng/L for QCM and 24.57 ng/L for SPR sensors. In conclusion, both QCM and SPR sensor systems showed good accuracy and precision, with recovery percentages between 90 and 92% and 87-93%, respectively. Furthermore, they have a fast response time, reusability, high selectivity and sensitivity and low limit of detection.en_US
dc.description.sponsorshipScientific and Technological Research Council (TUBITAK) of Turkey; [115Z126]en_US
dc.description.sponsorshipThis work was financially supported by the Scientific and Technological Research Council (TUBITAK) of Turkey and was assigned Project number: 115Z126. Authors are thankful to Dicle University Science and Technology Research and Application Center (DUBTAM) for providing laboratory facilities. Authors also thank to Professor Adil Denizli from Hacettepe University for kind contributions.en_US
dc.identifier.doi10.1016/j.msec.2019.04.056
dc.identifier.endpage491en_US
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.pmid31147019
dc.identifier.scopus2-s2.0-85064893495
dc.identifier.scopusqualityQ1
dc.identifier.startpage483en_US
dc.identifier.urihttps://doi.org/10.1016/j.msec.2019.04.056
dc.identifier.urihttps://hdl.handle.net/11468/15889
dc.identifier.volume102en_US
dc.identifier.wosWOS:000472241700046
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMaterials Science and Engineering C-Materials For Biological Applications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2,4-Dichlorophenoxyacetic Aciden_US
dc.subjectMolecular Imprintingen_US
dc.subjectQcmen_US
dc.subjectSensoren_US
dc.subjectSpren_US
dc.titleNovel QCM and SPR sensors based on molecular imprinting for highly sensitive and selective detection of 2,4-dichlorophenoxyacetic acid in apple samplesen_US
dc.titleNovel QCM and SPR sensors based on molecular imprinting for highly sensitive and selective detection of 2,4-dichlorophenoxyacetic acid in apple samples
dc.typeArticleen_US

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