Histopathological changes in the choroid plexus after traumatic brain injury in the rats: a histologic and immunohistochemical study

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dc.authorid0000-0002-5437-4003en_US
dc.authorid0000-0002-2353-1184en_US
dc.authorid0000-0001-7317-5467en_US
dc.contributor.authorÖzevren, Hüseyin
dc.contributor.authorDeveci, Engin
dc.contributor.authorTuncer, Mehmet Cudi
dc.date.accessioned2022-07-07T07:42:37Z
dc.date.available2022-07-07T07:42:37Z
dc.date.issued2018en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalıen_US
dc.descriptionPMID: 29569703
dc.description.abstractBackground: Traumatic brain injury (TBI) is in part associated with the disruption of the blood-brain barrier. In this study, we analysed the histopathological changes in E-cadherin and vascular endothelial growth factor (VEGF) expression after TBI in rats. Materials and methods: The rats were divided into two groups as the control and the trauma groups. Sprague-Dawley rats were subjected to TBI with a weight-drop device using 300 g/1 m weight-height impact. After 5 days of TBI, blood samples were taken under ketamine hydroxide anaesthesia and biochemical analyses were performed. The control and trauma groups were compared in terms of biochemical values. Results: There was no change in glutathione (GSH) levels and blood-brain barrier permeability. However, malondialdehyde (MDA) and myeloperoxidase (MPO) activity levels increased in the trauma group. In the histopathological examination, choroid plexus in the lateral ventricle, near the pia mater membrane, was removed. In the traumatic group, some of epithelial cells were hyperplasic. Some of them were peeled off the apical surface and had local degeneration. Conclusions: In addition, we observed congestion in capillary vessels and mononuclear cell infiltration around the vessels. After TBI, the increase in VEGF levels, vascular permeability, and interaction with VEGF receptors in endothelial cells lead to oedema of the vessel wall. On the other hand, E-cadherin expression decreased in the tight-junction structures between epithelial cells and basal membrane, resulting in an increase in cerebrospinal fluid in the intervillous area. (Folia Morphol 2018; 77, 4: 642–648)en_US
dc.identifier.citationÖzevren, H., Deveci, E.ve Tuncer, M. C. (2018). Histopathological changes in the choroid plexus after traumatic brain injury in the rats: a histologic and immunohistochemical studyen_US
dc.identifier.doi10.5603/FM.a2018.0029
dc.identifier.endpage648en_US
dc.identifier.issn0015-5659
dc.identifier.issue4en_US
dc.identifier.pmid29569703
dc.identifier.scopus2-s2.0-85056779429
dc.identifier.scopusqualityQ2
dc.identifier.startpage642en_US
dc.identifier.urihttps://journals.viamedica.pl/folia_morphologica/article/view/56956
dc.identifier.urihttps://hdl.handle.net/11468/10143
dc.identifier.volume77en_US
dc.identifier.wosWOS:000452416600004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzevren, Hüseyin
dc.institutionauthorDeveci, Engin
dc.institutionauthorTuncer, Mehmet Cudi
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofFolia Morphologica (Poland)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTraumatic brain injuryen_US
dc.subjectChoroid plexusen_US
dc.subjectVascular endothelial growth factor (VEGF)en_US
dc.subjectE-cadherinen_US
dc.subjectProliferating cell nuclear antigen (PCNA)en_US
dc.titleHistopathological changes in the choroid plexus after traumatic brain injury in the rats: a histologic and immunohistochemical studyen_US
dc.titleHistopathological changes in the choroid plexus after traumatic brain injury in the rats: a histologic and immunohistochemical study
dc.typeArticleen_US

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