7-Acetoxyhorminone from Salvia multicaulis Vahl. as Promising Inhibitor of 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase

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dc.authorid0000-0002-6202-1515en_US
dc.authorid0000-0002-2193-8386en_US
dc.authorid0000-0003-3888-5070en_US
dc.authorid0000-0002-7379-5436en_US
dc.contributor.authorYiğitkan, Serkan
dc.contributor.authorErtaş, Abdulselam
dc.contributor.authorSalmas, Ramin Ekhteiari
dc.contributor.authorFırat, Mehmet
dc.contributor.authorOrhan, İlkay Erdoğan
dc.date.accessioned2024-01-09T11:35:11Z
dc.date.available2024-01-09T11:35:11Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bililmleri Bölümüen_US
dc.description.abstract3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is a key enzyme involved in cholesterol biosynthesis and one of the most important targets for the treatment of hy-percholesterolemia. A limited number of studies on the HMG-CoA reductase inhibitory potential of natural products are available. Thus, in the current study, we aimed to test the HMG-CoA re-ductase inhibitory capacity of extracts from the roots and aerial parts of Salvia multicaulis Vahl., through activity-guided isolation. Our findings revealed that the root extract prepared with di-chloromethane–acetone (1:1) showed the highest inhibition (71.97 ± 0.37%) at 100 µg/mL. The extract was then initially fractionated by column chromatography and the obtained fractions were monitored by thin layer chromatography. Fractions which were similar to each other were combined and a total of 15 fractions were obtained. Further conventional chromatographic studies were carried out on the active fractions. Based on these fractions, 10 known compounds, compris-ing 9 terpenes and 1 steroid derivative in total, were isolated and their structures were verified by a combination of IT-TOF-MS, and 1D and 2D NMR techniques. According to the enzyme inhibition data of the identified compounds, 7-acetoxyhorminone exerted the highest inhibition (84.15 ± 0.10%, IC50 = 63.6 ± 1.21 µg/mL). The molecular docking experiments on 7-acetoxyhorminone and horminone indicated that both compounds strongly bind to the active site of the enzyme.en_US
dc.description.sponsorshipGazi University 02/2018-16en_US
dc.identifier.citationYiğitkan, S., Ertaş, A., Salmas, R. E., Fırat, M. ve Orhan, İ. E. (2022). 7-Acetoxyhorminone from Salvia multicaulis Vahl. as Promising Inhibitor of 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase. Pharmaceuticals, 15(2), 1-11.en_US
dc.identifier.doi10.3390/ph15020198
dc.identifier.endpage11en_US
dc.identifier.issn1424-8247
dc.identifier.issue2en_US
dc.identifier.pmid35215310
dc.identifier.scopus2-s2.0-85124225150
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.mdpi.com/1424-8247/15/2/198
dc.identifier.urihttps://hdl.handle.net/11468/13161
dc.identifier.volume15en_US
dc.identifier.wosWOS:000826760300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYiğitkan, Serkan
dc.institutionauthorErtaş, Abdulselam
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofPharmaceuticals
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectHMG-CoA reductaseen_US
dc.subjectHypercholesterolemiaen_US
dc.subjectSalviaen_US
dc.subjectTerpenoidsen_US
dc.title7-Acetoxyhorminone from Salvia multicaulis Vahl. as Promising Inhibitor of 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductaseen_US
dc.title7-Acetoxyhorminone from Salvia multicaulis Vahl. as Promising Inhibitor of 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase
dc.typeArticleen_US

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