Oral Anticoagulant Use and Long-Term Follow-Up Results in Patients with Non-valvular Atrial Fibrillation in Turkey AFTER-2 Study

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dc.contributor.authorGuzel, Tuncay
dc.contributor.authorAktan, Adem
dc.contributor.authorKilic, Raif
dc.contributor.authorArslan, Bayram
dc.contributor.authorArik, Baran
dc.contributor.authorYentur, Merve
dc.contributor.authorYildiz, Halil
dc.date.accessioned2024-04-24T17:25:04Z
dc.date.available2024-04-24T17:25:04Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to investigate the frequency of oral anticoagulant drugs and time in therapeutic range in patients receiving warfarin in addition to the epidemiological trial of non-valvular atrial fibrillation previously conducted in Turkey (The Atrial Fibrillation: Epidemiological Registry trial). Furthermore, the prevalence of major adverse events and mortality rates of the patients were evaluated during the long-term follow-up period. Methods: We created a national data registry for non-valvular atrial fibrillation patients, reflecting all geographic regions by population density. In that context, the study included all consecutive atrial fibrillation patients older than 18 years of age who were admitted to the cardiology outpatient clinic except for patients those with prosthetic heart valves and rheumatic mitral valve stenosis. Results: This study included 2592 patients from 35 different centers. The mean age was 68.7 +/- 11.1 years, and 55.5% of the patients were female. The most common comorbid diseases were chronic kidney disease (69%) and hypertension (65.5%). The time in therapeutic range rate in the general population was 40%, and the mortality rate at 5-year follow-up was 29.4%. Conclusion: The Atrial Fibrillation: Epidemiological Registry 2 study showed higher use of anticoagulant in non-valvular atrial fibrillation patients than in previous national studies. Furthermore, this study demonstrated that most of the non-valvular atrial fibrillation patients are in the high-risk group and the time in therapeutic range rates are still low in Turkey. As a result, this is a significant reason for switching from warfarin to non-K vitamin-dependent new oral anticoagulant treatments.en_US
dc.identifier.doi10.5152/AnatolJCardiol.2022.1597
dc.identifier.endpage576en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue7en_US
dc.identifier.pmid35791713
dc.identifier.startpage567en_US
dc.identifier.trdizinid1109651
dc.identifier.urihttps://doi.org/10.5152/AnatolJCardiol.2022.1597
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1109651
dc.identifier.urihttps://hdl.handle.net/11468/19924
dc.identifier.volume26en_US
dc.identifier.wosWOS:000825138100009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofAnatolian Journal of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtrial Fibrillationen_US
dc.subjectOral Anticoagulant Therapyen_US
dc.subjectEpidemiologyen_US
dc.subjectMortalityen_US
dc.titleOral Anticoagulant Use and Long-Term Follow-Up Results in Patients with Non-valvular Atrial Fibrillation in Turkey AFTER-2 Studyen_US
dc.titleOral Anticoagulant Use and Long-Term Follow-Up Results in Patients with Non-valvular Atrial Fibrillation in Turkey AFTER-2 Study
dc.typeArticleen_US

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