High plasma nesfatin-1 level in patients with major depressive disorder

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dc.contributor.authorAri, Mustafa
dc.contributor.authorOzturk, Oktay Hasan
dc.contributor.authorBez, Yasin
dc.contributor.authorOktar, Suleyman
dc.contributor.authorErduran, Dudu
dc.date.accessioned2024-04-24T16:18:17Z
dc.date.available2024-04-24T16:18:17Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: In the present study, our aim was to determine the changes in the plasma concentrations of a recently discovered peptide hormone nesfatin-1 in patients with major depressive disorder and then to make a comparison with the control group. Method: Subjects in the patient group were randomly selected from Mustafa Kemal University, Medical School, Research and Training Hospital, Psychiatry Department, Outpatient Clinic and subjects in the control group were selected from healthy volunteers. Healthy control subjects were matched in terms of weight and body mass index. Hamilton Depression Rating Scale (HAM-D) was applied to both groups. ELISA method was used for measurement of plasma nesfatin-1 levels. Results: The average nesfatin-1 level was statistically higher in patients with major depressive disorder than in the control group (p<0.001). A positive correlation was observed between plasma nesfatin-1 levels and HAM-D scores both in the patient group (r = 0.59, p<0.001) and in the control group (r = 0.58, p<0.001). Conclusion: Our findings suggest a possible relationship between major depressive disorder and high plasma nesfatin-1 level. (C) 2010 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.pnpbp.2010.12.004
dc.identifier.endpage500en_US
dc.identifier.issn0278-5846
dc.identifier.issn1878-4216
dc.identifier.issue2en_US
dc.identifier.pmid21163317
dc.identifier.scopus2-s2.0-79952901983
dc.identifier.scopusqualityQ1
dc.identifier.startpage497en_US
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2010.12.004
dc.identifier.urihttps://hdl.handle.net/11468/15948
dc.identifier.volume35en_US
dc.identifier.wosWOS:000289811200027
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofProgress in Neuro-Psychopharmacology & Biological Psychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDepressionen_US
dc.subjectFood Intakeen_US
dc.subjectMajor Depressive Disorderen_US
dc.subjectPlasma Nesfatin-1en_US
dc.subjectSatietyen_US
dc.titleHigh plasma nesfatin-1 level in patients with major depressive disorderen_US
dc.titleHigh plasma nesfatin-1 level in patients with major depressive disorder
dc.typeReview Articleen_US

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