Effects of daidzein on rat ovary against ischemia-reperfusion

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dc.contributor.authorToprak, Veysel
dc.contributor.authorAkalin, Senem Alkan
dc.contributor.authorOcal, Ece
dc.contributor.authorCavus, Yunus
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-04-24T17:18:09Z
dc.date.available2024-04-24T17:18:09Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: Our aim was to investigate protective effects of daidzein treatment on ischemia-reperfusion (I/R) injury-induced ovarian tissue by immunohistochemical techniques. Methods: Thirty Sprague Dawley female rats were categorized into three groups as sham, I/R group, and I/R+daidzein groups. Bloods were analyzed for malondialdehyde (MDA), glutathione peroxidase (GSH), and myeloperoxidase (MPO), and ovaries were processed for histological tissue protocol. Results: Both MDA and MPO values were increased in I/R group compared to sham and I/R+daidzein groups. GSH content was increased in I/R+daidzein group compared to I/R groups. In I/R group, theca and follicular cells were degenerated with apoptosis and dilatation and congestion, edema. In I/R+daidzein group, daidzein improved pathologies. In the I/R group, Bax expression was positive with follicular cells, granulosa cells and inflammatory cells. In the I/R+daidzein group, positive Bax reaction was observed in the epithelial, antral, and inflammatory cells. In I/R group, Bcl-2 reaction was in germinative epithelial cells, cells of antral follicle. In the I/R+daidzein group, Bcl-2 expression level was reduced after daidzein treatment. Conclusion: After the I/R procedure, ovarian cells and follicles were degenerated with apoptosis and inflammation. After daidzein treatment, Bax and Bcl-2 signal were decreased. It was observed that daidzein stopped the apoptotic process.en_US
dc.identifier.doi10.1590/acb384423
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.pmid37909594
dc.identifier.scopus2-s2.0-85175551419
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1590/acb384423
dc.identifier.urihttps://hdl.handle.net/11468/18633
dc.identifier.volume38en_US
dc.identifier.wosWOS:001094039300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOvaryen_US
dc.subjectIschemiaen_US
dc.subjectReperfusionen_US
dc.subjectPathologyen_US
dc.subjectHistologyen_US
dc.titleEffects of daidzein on rat ovary against ischemia-reperfusionen_US
dc.titleEffects of daidzein on rat ovary against ischemia-reperfusion
dc.typeArticleen_US

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