Ameliorating effects of CAPE on oxidative damage caused by pneumoperitoneum in rat lung tissue

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dc.contributor.authorDavarci, Isil
dc.contributor.authorAlp, Harun
dc.contributor.authorOzgur, Tumay
dc.contributor.authorKarcioglu, Murat
dc.contributor.authorTuzcu, Kasim
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorMotor, Sedat
dc.date.accessioned2024-04-24T17:33:13Z
dc.date.available2024-04-24T17:33:13Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe investigated the biochemical and histopathological effects of caffeic acid phenethyl ester (CAPE) against oxidative stress causing lung injury induced by pneumoperitoneum. Twenty-eight rats were selected at random and seven rats were assigned to each of the following groups. The control group (S) was subjected to a sham operation without pneumoperitoneum. The other groups were subjected to CO2 pneumoperitoneum 15 mmHg for 60 min. The laparoscopy group (L) had no additional drugs administered, the laparoscopy + alcohol (LA) group had 1 ml of 70% ethyl alcohol administered 1 h before the desufflation period, and the laparoscopy + CAPE (LC) group had CAPE administered at 10 mu mol/kg 1 h before the desufflation period. The total oxidative status levels of lung and plasma were significantly increased in the LA group as compared with the LC and S group. When the LC group was compared with the L group, there was a decrease in the level of total oxidant status and increase in the levels of total antioxidant status and paraoxonase in lung tissue. The level of total antioxidative status in the S group was increased compared with the L group in lung tissue and bronchoalveolar lavage fluid. TNF-alpha and IL-6 were found significantly elevated in the L group compared with the LC and S groups in bronchoalveolar lavage fluid. There was a similar increase in plasma levels of IL-6. These results were supported by histopathological examination. CAPE was found to considerably reduce oxidative stress and inflammation induced by pneumoperitoneum.en_US
dc.identifier.endpage1705en_US
dc.identifier.issn1940-5901
dc.identifier.issue7en_US
dc.identifier.pmid25126167
dc.identifier.scopus2-s2.0-84905654127
dc.identifier.scopusqualityN/A
dc.identifier.startpage1698en_US
dc.identifier.urihttps://hdl.handle.net/11468/20540
dc.identifier.volume7en_US
dc.identifier.wosWOS:000341256700010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaffeic Acid Phenethyl Esteren_US
dc.subjectPneumoperitoneumen_US
dc.subjectRaten_US
dc.subjectLungen_US
dc.subjectBronchoalveolar Lavageen_US
dc.titleAmeliorating effects of CAPE on oxidative damage caused by pneumoperitoneum in rat lung tissueen_US
dc.titleAmeliorating effects of CAPE on oxidative damage caused by pneumoperitoneum in rat lung tissue
dc.typeArticleen_US

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