Protective effects of recombinant human interleukin-4 administration on the hypoxia-reoxygenation-induced gastric and intestinal injury in rat pups

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dc.contributor.authorOzturk, H
dc.contributor.authorOzturk, H
dc.contributor.authorBuyukbayram, H
dc.date.accessioned2024-04-24T17:07:48Z
dc.date.available2024-04-24T17:07:48Z
dc.date.issued2005
dc.departmentDicle Üniversitesien_US
dc.description.abstractA total of 40 rat pups were randomly divided into 4 groups. Group 1 (sham) rats served as nonhypoxic controls. Group 2 (rhIL-4 treated/control) rats were subjected to H-O and were then returned to 3 hypoxia-reoxygenation [H-O]/untreated) rats were subjected to H-O and were then returned to their mothers. Group 4 (H-O/rhIL-4 treated) rats were subjected to H/O and were treated with rhIL-4 for the next 3 days. All animals were killed on day 4 and gastric and intestional specimens were obtained to determine the tissue level of malondialdehyde (MDA) and histological changes. In group 3 MDA levels were significantly increased compared with groups 1,2, and 4. In group 4, MDA levels were not significantly different compared with group 3. The gastric and intestinal injury score were significantly group 3 and 4 rats compared with group 1 and 2. However this increase was lower in. group 4 rats compared with group 3. In group 3, after hypoxia following reoxygenation, exfoliation and necrosis of superficial cells, blood cell infiltratian, and structural alterations on the two-third parts of the glandular pits, and bleeding erosions developed in all stomachs. Treatment with rhIL-4 produced a reduction of exfoliation of superficial cells, hemorrhage, and blood cell infiltration. In group 3 animals, destruction of villi and crypts of ileum and in some cases extension to the muscularis were noticed. In contrast, in the rats treated with rhIL-4, lesions were, limited essentially to the very tips of the villi. This study found beneficial effects of rhlL-4 in an experimental model of hypoxio-induced gastric and intestinalal injury.en_US
dc.identifier.doi10.1080/15227950500503769
dc.identifier.endpage358en_US
dc.identifier.issn1551-3815
dc.identifier.issn1551-3823
dc.identifier.issue6en_US
dc.identifier.pmid16761563
dc.identifier.scopus2-s2.0-33745100720
dc.identifier.scopusqualityQ2
dc.identifier.startpage347en_US
dc.identifier.urihttps://doi.org/10.1080/15227950500503769
dc.identifier.urihttps://hdl.handle.net/11468/17005
dc.identifier.volume24en_US
dc.identifier.wosWOS:000236543200005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofFetal and Pediatric Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytokineen_US
dc.subjectGastric Injuryen_US
dc.subjectHypoxic Mucosal Injuryen_US
dc.subjectInterleukin-4en_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.titleProtective effects of recombinant human interleukin-4 administration on the hypoxia-reoxygenation-induced gastric and intestinal injury in rat pupsen_US
dc.titleProtective effects of recombinant human interleukin-4 administration on the hypoxia-reoxygenation-induced gastric and intestinal injury in rat pups
dc.typeArticleen_US

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