Strong association of HMB-45 expression with renal angiomyolipoma

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dc.contributor.authorYaldiz, M
dc.contributor.authorKilinc, N
dc.contributor.authorOzdemir, E
dc.date.accessioned2024-04-24T17:38:09Z
dc.date.available2024-04-24T17:38:09Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Angiomyolipoma (AML) is a benign neoplasm consisting of varying mixtures of smooth muscle, blood vessels and fat. Although, most of these tumors are easy to recognize, some may pose a diagnostic dilemma due to unusual histologic features. Recently, it was suggested that melanosome-associated protein (HMB-45) immunoreactivity may be used for diagnostic confirmation of several neoplasm. The aim of this study is to analyze the diagnostic efficacy of HMB-45 in patients with AML. Methods. This study was carried out at the Faculty of Medicine, Department of Pathology, Dicle University, Diyarbakir, Turkey, during the period January 2000 to September 2003. HMB-45 immunoreactivity was analyzed in 6 patients with AML and in 34 patients with other renal and retroperitoneal pathologies, including 10 nephrectomized patients for non-neoplastic reasons by means of immunohistochemistry. Results: Patients with AML were positive for HMB-45. Whereas, HMB-45 immunoreactivity was negative in all of the histologic specimens from the patients with renal cell carcinoma, retroperitoneal sarcomas, Wilms' tumor, lipoma, leiomyoma, and nephrectomized kidneys of non-neoplastic reason. The association of AML with HMB-45 immunoreactivity was highly significant (p<0.001). Conclusion: Our findings suggest that HMB-45 may not be a melanocyte-restricted marker, and can be useful in differential diagnosis between AML and other tumors seen in kidney and retroperitoneal region.en_US
dc.identifier.endpage1023en_US
dc.identifier.issn0379-5284
dc.identifier.issue8en_US
dc.identifier.pmid15322591
dc.identifier.scopus2-s2.0-4544279082
dc.identifier.scopusqualityQ2
dc.identifier.startpage1020en_US
dc.identifier.urihttps://hdl.handle.net/11468/21346
dc.identifier.volume25en_US
dc.identifier.wosWOS:000223702800009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSaudi Med Jen_US
dc.relation.ispartofSaudi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleStrong association of HMB-45 expression with renal angiomyolipomaen_US
dc.titleStrong association of HMB-45 expression with renal angiomyolipoma
dc.typeArticleen_US

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