The effect of bevacizumab and 5-Fluorouracil combination on epidural fibrosis in a rat laminectomy model

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dc.contributor.authorOzkan, U.
dc.contributor.authorOsun, A.
dc.contributor.authorSamancioglu, A.
dc.contributor.authorErcan, S.
dc.contributor.authorFirat, U.
dc.contributor.authorKemaloglu, S.
dc.date.accessioned2024-04-24T17:38:18Z
dc.date.available2024-04-24T17:38:18Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: An animal model of laminectomy in rats was used to study scar tissue formation around the spinal cord. Bevacizumab (BV) [a recombinant, humanized, monoclonal antibody targeting vascular endothelial growth factor], 5-Fluorouracil (5-FU) and BV+5-FU was tested in this system for its ability to decrease fibrous tissue formation. MATERIALS AND METHODS: Twenty-eight Sprague Dawley rats were used in this sudy. Rats were divided into four groups; a control group, a BV group, a 5-FU group and a BV+5-FU group. L12 laminectomies were performed on the rats. The medicated groups were treated with topical drug administration. After 6 weeks, the rats were sacrified and histologic sections prepared from the spines were examined and graded by a pathologist. Epidural fibrosis and fibroblast density were evaluated under light microscope. RESULTS: BV (Avastin: Genentech, San Francisco, CA, USA) significantly reduced the density of the scar tissue undermining the laminas (p < 0.005). Monotherapy with 5-FU did not change the scar formation in the back (p = 0.317). Combination of 5-FU and BV was more effective on reducing the epidural fibrosis after laminectomy on rats (p < 0.001). CONCLUSIONS: Bevacizumab reduced the spinal epidural fibrosis significantly that developed in rats after laminectomy and 5-Fluorouracil combination had a synergic effect. Further investigations under the light of these findings may help to reduce epidural fibrosis formation after laminectomy.en_US
dc.identifier.endpage100en_US
dc.identifier.issn1128-3602
dc.identifier.issue1en_US
dc.identifier.pmid24452949
dc.identifier.scopus2-s2.0-84896959999
dc.identifier.scopusqualityQ2
dc.identifier.startpage95en_US
dc.identifier.urihttps://hdl.handle.net/11468/21398
dc.identifier.volume18en_US
dc.identifier.wosWOS:000331436700014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLaminectomyen_US
dc.subjectEpidural Fibrosisen_US
dc.subjectBevacizumaben_US
dc.subject5-Fluorouracilen_US
dc.titleThe effect of bevacizumab and 5-Fluorouracil combination on epidural fibrosis in a rat laminectomy modelen_US
dc.titleThe effect of bevacizumab and 5-Fluorouracil combination on epidural fibrosis in a rat laminectomy model
dc.typeArticleen_US

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