BDNF and cortisol levels in children with or without post-traumatic stress disorder after sustaining sexual abuse

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dc.contributor.authorSimsek, Seref
dc.contributor.authorUysal, Cem
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorYuksel, Tugba
dc.contributor.authorAktas, Huseyin
dc.date.accessioned2024-04-24T16:18:18Z
dc.date.available2024-04-24T16:18:18Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: There are studies reporting that cortisol and brain-derived neurotropic factor (BDNF) play a role in the pathophysiology of post-traumatic stress disorder (PTSD). However, up-to-date no study evaluated the relationship between PTSD and the levels of cortisol and BDNF in children and adolescents who have sustained trauma. The aim of this study was to investigate whether BDNF, cortisol and adrenocorticotropine (ACTH) levels differ between individuals who developed PTSD or not following a sexual trauma. Method: The study included 55 children aged between 6 and 17 years who sustained sexual assault (M/F: 13/42). The patients were divided into two groups, with or without PTSD based on the results of a structured psychiatric interview (K-SADS-PL and CAPS-CA). Of the participants, 49% (n = 27) were diagnosed with PTSD. Cortisol, ACTH, and BDNF levels were evaluated using the ELISA method. Results: There were no significant differences between patients with or without PTSD in terms of cortisol, ACTH, BDNF levels. There were no correlations between CAPS-CA scores and cortisol, ACTH, and BDNF levels in patients with or without PTSD. In patients with PTSD, decreased cortisol levels were found with increasing time after trauma, and no significant correlation was found with the cortisol levels in patients without PTSD. Conclusion: Although no significant association was found between biochemical parameters and the presence or severity of PTSD; decreasing cortisol levels with increasing time after trauma in patients with PTSD suggest that cortisol might have played a role in the pathophysiology of this disorder. (C) 2015 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.psyneuen.2015.02.017
dc.identifier.endpage51en_US
dc.identifier.issn0306-4530
dc.identifier.pmid25800148
dc.identifier.scopus2-s2.0-84927779179
dc.identifier.scopusqualityQ1
dc.identifier.startpage45en_US
dc.identifier.urihttps://doi.org/10.1016/j.psyneuen.2015.02.017
dc.identifier.urihttps://hdl.handle.net/11468/15980
dc.identifier.volume56en_US
dc.identifier.wosWOS:000354142100006
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPsychoneuroendocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBdnfen_US
dc.subjectCortisolen_US
dc.subjectHpa Axisen_US
dc.subjectPtsden_US
dc.subjectSexual Abuseen_US
dc.subjectTraumaen_US
dc.titleBDNF and cortisol levels in children with or without post-traumatic stress disorder after sustaining sexual abuseen_US
dc.titleBDNF and cortisol levels in children with or without post-traumatic stress disorder after sustaining sexual abuse
dc.typeArticleen_US

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