Low fetuin-A level in migraine: a case-control study

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dc.contributor.authorTanriverdi, Mehmet Halis
dc.contributor.authorVarol, Sefer
dc.contributor.authorArikanoglu, Adalet
dc.contributor.authorBucaktepe, Pakize Gamze Erten
dc.contributor.authorCelepkolu, Tahsin
dc.contributor.authorAkil, Esref
dc.contributor.authorYuksel, Hatice
dc.date.accessioned2024-04-24T16:02:01Z
dc.date.available2024-04-24T16:02:01Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractMigraine is a type of primary headache which is caused by the alterations in trigeminovascular system. Migraine attacks are associated with neurovascular inflammation of the cerebral and extracerebral vessels, but its pathophysiological mechanisms have not still been fully delineated. Also, migraine has been found to be associated with higher risks for various metabolic disorders. Thus, we aimed to investigate the matrix metalloproteinases (MMP), fetuin-A, ghrelin, and omentin levels which have important roles in metabolic disorders and inflammation, and to examine their relationship with migraine subtypes and attack frequency. Forty-nine migraine patients and 30 age- and sex-matched healthy control subjects were enrolled. Migraine diagnosis was confirmed according to the International Classification of Headache Disorders-II diagnostic criteria. Analyses of MMP9,MMP3, ghrelin, omentin, and fetuin-A were performed by the ELISA method. Fetuin-A, MMP-9, and MMP-3 levels were significantly lower in migraine than controls (p < 0.05). There were no significant differences between groups with respect to omentin and ghrelin (p > 0.05). In migraine patients, serum fetuin-A levels were positively correlated with MMP-9 and negatively correlated with MMP-3. MMP-3, MMP-9, fetuin-A, omentin and ghrelin levels did not correlate with age, disease duration, or frequency of migraine headache (p > 0.05). Migraine patients have lower fetuin-A, MMP-3 and MMP-9 levels than healthy individuals. Migraine patients have low fetuin-A levels, which may be related to the pathogenesis of migraine. The importance and impact of our findings on the pathogenesis, characteristics, and treatment of migraine needs to be investigated in further detailed studies.en_US
dc.identifier.doi10.1007/s10072-013-1504-8
dc.identifier.endpage275en_US
dc.identifier.issn1590-1874
dc.identifier.issn1590-3478
dc.identifier.issue2en_US
dc.identifier.pmid23925572en_US
dc.identifier.scopus2-s2.0-84893841556en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage271en_US
dc.identifier.urihttps://doi.org/10.1007/s10072-013-1504-8
dc.identifier.urihttps://hdl.handle.net/11468/14569
dc.identifier.volume35en_US
dc.identifier.wosWOS:000330980100018
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.relation.ispartofNeurological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMigraineen_US
dc.subjectFetuin-Aen_US
dc.subjectMatrix Metalloproteinaseen_US
dc.subjectOmentinen_US
dc.subjectGhrelinen_US
dc.titleLow fetuin-A level in migraine: a case-control studyen_US
dc.typeArticleen_US

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