The effect of angiotensin II type-1 receptor gene polymorphisms on doppler blood flow parameters of carotid and brachial arteries in patients with myocardial infarction

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dc.contributor.authorOzturk, Onder
dc.contributor.authorOzturk, Unal
dc.contributor.authorBilici, Aslan
dc.date.accessioned2024-04-24T17:11:36Z
dc.date.available2024-04-24T17:11:36Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Genetic influence on Doppler blood flow parameters of carotid and brachial arteries (BA) is uncertain. We investigated the relationship between the angiotensin II type-1 receptor (AT1R) gene polymorphism and the blood flow characteristics of common carotid arteries (CCA) and BA by color Doppler ultrasound (CDUS) in patients with a first anterior acute myocardial infarction (AMI). Methods and Results: Sixty-seven patients (15 women and 52 men), aged 25-77 years, with anterior AMI were studied. The AT1R genotypes were established. Based on the polymorphism of the AT1R, they were classified into three groups: AT1R AA genotype (Group1, n = 42 patients), AT1R AC genotype (Group 2, n = 17 patients), and AT1R CC genotype (Group 3, n = 8 patients). Peak-systolic velocity (PSV) and end-diastolic velocity (EDV) of right and left CCA, PSV of right BA, and intimal-medial thickness (IMT) of both CCA were measured by CDUS. All results evaluated statistically. The AT1R genotypes were distributed as follows: 63% AA, 25% AC, and 12% CC. PSV of BA and both CCA were higher in patients with CC and AC than AA (P < 0.05). Also, IMT of both CCA were also higher in the same groups (P < 0.05). Conclusions: Our results suggest that AT1R gene polymorphism influences Doppler blood flow parameters of both BA and CCA, and IMT of CCA. Although further studies are required.en_US
dc.identifier.doi10.1111/j.1540-8175.2006.00258.x
dc.identifier.endpage541en_US
dc.identifier.issn0742-2822
dc.identifier.issn1540-8175
dc.identifier.issue7en_US
dc.identifier.pmid16911325
dc.identifier.scopus2-s2.0-33746500204
dc.identifier.scopusqualityQ3
dc.identifier.startpage536en_US
dc.identifier.urihttps://doi.org/10.1111/j.1540-8175.2006.00258.x
dc.identifier.urihttps://hdl.handle.net/11468/17631
dc.identifier.volume23en_US
dc.identifier.wosWOS:000239332900002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEchocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAt1r Gene Polymorphismen_US
dc.subjectCommon Carotid Arteryen_US
dc.subjectBrachial Arteryen_US
dc.subjectDoppler Ultrasonographyen_US
dc.subjectMyocardial Infarctionen_US
dc.titleThe effect of angiotensin II type-1 receptor gene polymorphisms on doppler blood flow parameters of carotid and brachial arteries in patients with myocardial infarctionen_US
dc.titleThe effect of angiotensin II type-1 receptor gene polymorphisms on doppler blood flow parameters of carotid and brachial arteries in patients with myocardial infarction
dc.typeArticleen_US

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