Role of Propolis on Oxidative Stress in Fish Brain

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dc.contributor.authorKakoolaki, Shapour
dc.contributor.authorTalas, Zeliha Selamoglu
dc.contributor.authorCakir, Oguz
dc.contributor.authorCiftci, Osman
dc.contributor.authorOzdemir, Ilknur
dc.date.accessioned2024-04-24T17:38:00Z
dc.date.available2024-04-24T17:38:00Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction: Cypermethrin causes its neurotoxic effect through voltage-dependent sodium channels and integral protein ATPases in the neuronal membrane. Brain and nerve damage are often associated with low residual level of pesticides. In vitro and in vivo studies have also shown that pesticides cause free radical-mediated tissue damage in brain. Propolis has antioxidant properties. The main chemical classes found in propolis are flavonoids and phenolics. Bioflavonoids are antioxidant molecules that play important roles in scavenging free radicals, which are produced in neurodegenerative diseases and aging. Methods: To determine the protective role of propolis, rainbow trouts were treated with cypermethrin, followed by biochemical analyses of brain tissue. Fish were divided into four groups: control, propolis-treated, cypermethrin-treated, and cypermethrin+propolis-treated. Results: In fish brains, catalase (CAT) activity decreased (P=0.001) and malondialdehyde (MDA) level increased (P=0.001) in cypermethrin-treated group compared to control group. In cypermethrin+propolis-treated group CAT activity increased (P=0.001) and MDA level decreased (P=0.001) compared to cypermethrin group. Discussion: The results demonstrated that the negative effects, observed as a result of cypermethrin treatment, could be reversed by adding supplementary propolis. Propolis may improve some biochemical markers associated with oxidative stress in fish brain, after exposure to cypermethrin.en_US
dc.description.sponsorshipNigde University Research Funden_US
dc.description.sponsorshipNigde University Research Fund (FEB 2007/13) is gratefully acknowledged for support of this work.en_US
dc.identifier.endpage158en_US
dc.identifier.issn2008-126X
dc.identifier.issn2228-7442
dc.identifier.issue2en_US
dc.identifier.pmid25337342
dc.identifier.scopus2-s2.0-84880603568
dc.identifier.scopusqualityQ3
dc.identifier.startpage153en_US
dc.identifier.urihttps://hdl.handle.net/11468/21285
dc.identifier.volume4en_US
dc.identifier.wosWOS:000215381500008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherIran Univ Medical Sciencesen_US
dc.relation.ispartofBasic and Clinical Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrainen_US
dc.subjectCypermethrinen_US
dc.subjectOxidative Stressen_US
dc.subjectPropolisen_US
dc.subjectRainbow Trouten_US
dc.titleRole of Propolis on Oxidative Stress in Fish Brainen_US
dc.titleRole of Propolis on Oxidative Stress in Fish Brain
dc.typeArticleen_US

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