Steroid responsiveness of children with idiopathic nephrotic syndrome in southeastern region of Turkey

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dc.contributor.authorDavutoglu, Mehmet
dc.contributor.authorEce, Aydin
dc.contributor.authorBilici, Meki
dc.contributor.authorDagli, Abdullah
dc.date.accessioned2024-04-24T16:24:39Z
dc.date.available2024-04-24T16:24:39Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground. Our aim was to determine the prognostic factors effective in the response to steroid treatment and relapse frequency. Patients and Methods. In this study, we evaluated 84 children with idiopathic nephrotic syndrome followed-up from 1997-2002. The variables were analyzed with respect to medical history, physical examination, laboratory findings, response to treatment, and factors associated with remissions and relapses. Our study group consisted of 62 children with minimal change nephrotic syndrome (MCNS), 11 children with focal segmental glomerulosclerosis (FSGS), and 11 children with diffuse mesangial proliferation (DMP). Results. According to response to steroids; 57.1% were steroid-sensitive with infrequent relapses, 22.6% were steroid-dependent with frequent relapses, and 20.2% were steroid-non-responders. Significantly high non-responder ratios to steroids were found in children with initial hypertension and hematuria (p < 0.05). Although patients older than six years were found to be associated with steroid non-response (p < 0.05), the number of relapses were found to be increased with an increasing number of infections (p < 0.05). The time period for the first relapse was found to be statistically correlated with relapse numbers of the first 6 (p = 0.001) and 12 (p = 0.01) months. Conclusion. The time span between initial presentation and remission and the number of infections were significant for relapse frequency. The existence of hematuria and hypertension and age greater than 6 years at initial presentation were associated with steroid non-responsiveness. The likelihood of developing resistance to the treatment should be emphasized early to the parents of patients bearing these risk factors, and hence the possible disappointment in the family should be prevented.en_US
dc.identifier.doi10.1080/08860220701573624
dc.identifier.endpage859en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue7en_US
dc.identifier.pmid17994455
dc.identifier.scopus2-s2.0-36248931605
dc.identifier.scopusqualityQ2
dc.identifier.startpage855en_US
dc.identifier.urihttps://doi.org/10.1080/08860220701573624
dc.identifier.urihttps://hdl.handle.net/11468/16801
dc.identifier.volume29en_US
dc.identifier.wosWOS:000250641200013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIdiopathic Nephrotic Syndromeen_US
dc.subjectRisk Factorsen_US
dc.subjectSteroiden_US
dc.subjectNon-Responderen_US
dc.subjectSoutheast Anatoliaen_US
dc.titleSteroid responsiveness of children with idiopathic nephrotic syndrome in southeastern region of Turkeyen_US
dc.titleSteroid responsiveness of children with idiopathic nephrotic syndrome in southeastern region of Turkey
dc.typeArticleen_US

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