Neuroprotective effects of carvacrol and pomegranate against methotrexate-induced toxicity in rats

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dc.contributor.authorCelik, F.
dc.contributor.authorGocmez, C.
dc.contributor.authorBozkurt, M.
dc.contributor.authorKaplan, I.
dc.contributor.authorKamasak, K.
dc.contributor.authorAkil, E.
dc.contributor.authorDogan, E.
dc.date.accessioned2024-04-24T17:37:40Z
dc.date.available2024-04-24T17:37:40Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBACKGROUND: Studies related to the use of various antioxidant and anti-inflammatory drugs to decrease the toxic side effects related to MTX have been carried out. However, since no medicine providing full protection against the side effects of MTX has been discovered, the discovery of new agents is required. AIM: The aim of this study was to determine whether methotrexate (MTX) causes oxidative stress and an inflammatory response in sciatic nerve, as well as whether carvacrol (CAR) and pomegranate (POM) have protective effects against the resulting oxidative stress and inflammatory response. MATERIALS AND METHODS: 32 adult male Wistar albino rats were used in the study. The animals were divided into 4 groups: Group C: the rats were not given any medication; Group MTX: On study day 2, the rats were given a single dose of 20 mg/kg MTX, administered intraperitoneally; Group MTX+CAR: On study day one, the rats were administered a single dose of 73 mg/kg CAR intraperitoneally. On study day two, a single dose of 20 mg/kg MTX was administered intraperitoneally; Group MTX+POM: For seven days starting from the study day one, rats were given 225 mg/kg POM extract once a day through orogastric gavage. On study day two, a single dose of 20 mg/kg MTX was administered intraperitoneally. All animals were sacrificed on the day eight. TOS, TAS, MDA, TNF-alpha and IL-1 beta levels were evaluated in the sciatic nerve tissue. RESULTS: In comparison to the control group, a decrease in TAS levels and an increase in TOS, MDA, IL-1 beta and TNF-alpha levels were detected in the MTX group. Compared to the MTX group, the MTX+CAR group had a significant increase in TAS level and significant decreases in TOS, MDA, IL-1 beta and TNF-alpha levels. In comparison to the MTX group, the MTX+POM group had a significant decrease in MDA, IL-1 beta and TNF-alpha levels. When the MTX+CAR and MTX+POM groups were compared, the TNF-alpha level measured was lower in the MTX+CAR group. CONCLUSIONS: In this work, we have shown that MTX causes a significant oxidative stress and inflammatory response in rats' sciatic nerve tissue and that CAR had an antioxidant effect in this system. Furthermore, we have proven, for the first time, that both CAR and POM decreased the pro-inflammatory response.en_US
dc.description.sponsorshipDUBAP (Dicle University Coordination Committee of Scientific Research Projects)en_US
dc.description.sponsorshipThis work was supported by financial support and sponsorship: The authors thank DUBAP (Dicle University Coordination Committee of Scientific Research Projects) for scientific and financial support.en_US
dc.identifier.endpage2993en_US
dc.identifier.issn1128-3602
dc.identifier.issue22en_US
dc.identifier.pmid24302176en_US
dc.identifier.scopus2-s2.0-84891777654en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2988en_US
dc.identifier.urihttps://hdl.handle.net/11468/21115
dc.identifier.volume17en_US
dc.identifier.wosWOS:000328085300002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMethotrexate-Related Neurotoxicityen_US
dc.subjectCarvacrolen_US
dc.subjectPomegranateen_US
dc.titleNeuroprotective effects of carvacrol and pomegranate against methotrexate-induced toxicity in ratsen_US
dc.typeArticleen_US

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