Kidney growth and renal functions under the growth hormone replacement therapy in children

Basit Öğe Kaydı
dc.contributor.authorEce, Aydin
dc.contributor.authorCetinkaya, Semra
dc.contributor.authorEksioglu, Secil
dc.contributor.authorSenel, Saliha
dc.contributor.authorOzkasap, Serdar
dc.contributor.authorGinis, Tayfur
dc.contributor.authorSen, Velat
dc.date.accessioned2024-04-24T17:20:28Z
dc.date.available2024-04-24T17:20:28Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to investigate the kidney growth and renal functions in children receiving recombinant human growth hormone (rhGH) treatment. Materials and methods: A total of 37 children who received rhGH for 1.5 years before the study was started and 48 healthy controls were included at first evaluation. Hormone levels were determined and kidney sizes were measured by ultrasound. Kidney functions were assessed by serum creatinine and estimated glomerular filtration rate (eGFR). After 3 years of first evaluation, 23 patients were re-assessed. Results: Kidney sizes were found to be lower in rhGH received children compared with controls at first evaluation (p<0.05). Significant positive correlations were found between anthropometric measurements and kidney length and kidney volume (p<0.05). Height was the most significant predictor of kidney volume in rhGH received children (p<0.001). After 3-years of follow-up significantly increases were found in kidney length and volume compared with the first measurements (p<0.05). Increase percentage of body height was similar to increasing percent of kidney length and liver long axis (14.2%, 11.7.1% and 7.7%, respectively, p>0.05). Although no abnormal renal function test results were found at first and second evaluations; rhGH received children had significantly lower eGFR, at first evaluation, compared with controls; however, renal functions significantly increased after 3 years of follow-up (p<0.05). Conclusions: In conclusion, effect rhGH treatment on kidney growth is parallel to growth in body height and other visceral organs. A 3-years rhGH treatment resulted in significant increases in renal functions.en_US
dc.identifier.doi10.3109/0886022X.2013.875834
dc.identifier.endpage513en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue4en_US
dc.identifier.pmid24456095
dc.identifier.scopus2-s2.0-84898936613
dc.identifier.scopusqualityQ2
dc.identifier.startpage508en_US
dc.identifier.urihttps://doi.org/10.3109/0886022X.2013.875834
dc.identifier.urihttps://hdl.handle.net/11468/19068
dc.identifier.volume36en_US
dc.identifier.wosWOS:000334936400004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofRenal Failure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChildrenen_US
dc.subjectGrowth Hormone Deficiencyen_US
dc.subjectIgf-1en_US
dc.subjectRenal Functionsen_US
dc.subjectRenal Growthen_US
dc.titleKidney growth and renal functions under the growth hormone replacement therapy in childrenen_US
dc.titleKidney growth and renal functions under the growth hormone replacement therapy in children
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu