Evaluation of serum inflammatory markers in treatment-resistant manic patients and adequate responder manic patients

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dc.contributor.authorBulut, Mahmut
dc.contributor.authorCati, Songul
dc.contributor.authorGunes, Mehmet
dc.contributor.authorKaya, Mehmet Cemal
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorOzkan, Mustafa
dc.date.accessioned2024-04-24T16:18:18Z
dc.date.available2024-04-24T16:18:18Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractMania is accompanied with immune activation as indicated by increased pro-inflammatory cytokines, acute phase proteins; and carcinoembryonic antigen (CEA) is known to accompany signs of immune-inflammatory responses in bipolar disorder (BD) and medical disorders. In this study, it was aimed to compare high sensitivity C-reactive protein (hsCRP), CEA levels and white blood cells (WBCs) counts in the treatment-resistant BD (Group 3), the treatment-responsive BD patients (Group 2), and the healthy control group (Group 1). The socio-demographic data form, the Young Mania Rating Scale (YMRS), the Hamilton Depression Rating Scale (HDRS), and the Clinical Global Impression Severity of Illness (CGI-S) Scale were applied to the patients. In Group 3, the WBCs counts, and CEA levels were significantly higher than the other two groups. There was a positive correlation between WBCs counts and YMRS and CGI-S scores in all manic patients. There was a positive correlation between CEA levels and YMRS, HDRS and CGI-S in manic patients. This study shows that there is an activation of the immune-inflammatory response system in treatment resistant manic patients; and, WBCs counts and CEA levels are associated with severity of disease in manic patients.en_US
dc.identifier.doi10.1016/j.psychres.2018.12.073
dc.identifier.endpage79en_US
dc.identifier.issn0165-1781
dc.identifier.pmid30579185
dc.identifier.scopus2-s2.0-85058623747
dc.identifier.scopusqualityQ1
dc.identifier.startpage73en_US
dc.identifier.urihttps://doi.org/10.1016/j.psychres.2018.12.073
dc.identifier.urihttps://hdl.handle.net/11468/15979
dc.identifier.volume272en_US
dc.identifier.wosWOS:000460994400011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofPsychiatry Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBipolar Disorderen_US
dc.subjectTreatment-Resistant Maniaen_US
dc.subjectInflammationen_US
dc.subjectHscrpen_US
dc.subjectCeaen_US
dc.subjectWbcen_US
dc.titleEvaluation of serum inflammatory markers in treatment-resistant manic patients and adequate responder manic patientsen_US
dc.titleEvaluation of serum inflammatory markers in treatment-resistant manic patients and adequate responder manic patients
dc.typeArticleen_US

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