Pharmacokinetics of cefquinome in red-eared slider turtles (Trachemys scripta elegans) after single intravenous and intramuscular injections

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dc.contributor.authorUney, K.
dc.contributor.authorAltan, F.
dc.contributor.authorCetin, G.
dc.contributor.authorAboubakr, M.
dc.contributor.authorDik, B.
dc.contributor.authorSayin, Z.
dc.contributor.authorEr, A.
dc.date.accessioned2024-04-24T17:11:46Z
dc.date.available2024-04-24T17:11:46Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe purpose of this study was to evaluate the pharmacokinetics of cefquinome (CFQ) following single intravenous (IV) or intramuscular (IM) injections of 2mg/kg body weight in red-eared slider turtles. Plasma concentrations of CFQ were determined by high-performance liquid chromatography and analyzed using noncompartmental methods. The pharmacokinetic parameters following IV injection were as follows: elimination half-life (t(1/2z)) 21.73 +/- 4.95hr, volume of distribution at steady-state (V-dss) 0.37 +/- 0.11L/kg, area under the plasma concentration-time curve (AUC(0-)) 163 +/- 32ghr(-1)ml(-1), and total body clearance (Cl-T) 12.66 +/- 2.51 mlhr(-1)kg(-1). The pharmacokinetic parameters after IM injection were as follows: peak plasma concentration (C-max) 3.94 +/- 0.84g/ml, time to peak concentration (T-max) 3hr, t(1/2z) 26.90 +/- 4.33hr, and AUC(0-) 145 +/- 48ghr(-1)ml(-1). The bioavailability after IM injection was 88%. Data suggest that CFQ has a favorable pharmacokinetic profile with a long half-life and a high bioavailability in red-eared slider turtles. Further studies are needed to establish a multiple dosage regimen and evaluate clinical efficacy.en_US
dc.identifier.doi10.1111/jvp.12448
dc.identifier.endpageE44en_US
dc.identifier.issn0140-7783
dc.identifier.issn1365-2885
dc.identifier.issue1en_US
dc.identifier.pmid28833214
dc.identifier.scopus2-s2.0-85040036761
dc.identifier.scopusqualityQ1
dc.identifier.startpageE40en_US
dc.identifier.urihttps://doi.org/10.1111/jvp.12448
dc.identifier.urihttps://hdl.handle.net/11468/17715
dc.identifier.volume41en_US
dc.identifier.wosWOS:000419403100007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCefquinomeen_US
dc.subjectPharmacokineticsen_US
dc.subjectRed-Eared Slider Turtleen_US
dc.titlePharmacokinetics of cefquinome in red-eared slider turtles (Trachemys scripta elegans) after single intravenous and intramuscular injectionsen_US
dc.titlePharmacokinetics of cefquinome in red-eared slider turtles (Trachemys scripta elegans) after single intravenous and intramuscular injections
dc.typeArticleen_US

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