Are oxidative stress markers useful to distinguish schizoaffective disorder from schizophrenia and bipolar disorder?

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dc.contributor.authorBulbul, Feridun
dc.contributor.authorVirit, Osman
dc.contributor.authorAlpak, Gokay
dc.contributor.authorUnal, Ahmet
dc.contributor.authorBulut, Mahmut
dc.contributor.authorKaya, Mehmet Cemal
dc.contributor.authorAltindag, Abdurrahman
dc.date.accessioned2024-04-24T16:19:01Z
dc.date.available2024-04-24T16:19:01Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective Schizoaffective disorder is a disease with both affective and psychotic symptoms. In this study, we aimed to compare oxidative metabolism markers of schizoaffective disorder, bipolar disorder and schizophrenic patients. Furthermore, we also aimed to investigate whether schizoaffective disorder could be differentiated from schizophrenia and bipolar disorder in terms of oxidative metabolism. Methods Total oxidant status (TOS) and total antioxidant status (TAS) were measured in the blood samples that were collected from schizoaffective patients (n = 30), bipolar disorder patients (n = 30) and schizophrenic patients (n = 30). Oxidative stress index (OSI) was calculated by dividing TOS by TAS. Results TOS and OSI were found to be higher in patients with schizoaffective disorder compared with those in schizophrenia and bipolar disorder patients. TAS was not significantly different between the groups. Conclusion Schizoaffective disorder was found to be different from bipolar disorder and schizophrenia in terms of oxidative parameters. This result may indicate that schizoaffective disorder could differ from bipolar disorder and schizophrenia in terms of biochemical parameters. Increased TOS levels observed in schizoaffective disorder may suggest poor clinical course and may be an indicator of poor prognosis.en_US
dc.identifier.doi10.1017/neu.2013.44
dc.identifier.endpage124en_US
dc.identifier.issn1601-5215
dc.identifier.issue2en_US
dc.identifier.pmid24855890
dc.identifier.scopus2-s2.0-84898649351
dc.identifier.scopusqualityQ1
dc.identifier.startpage120en_US
dc.identifier.urihttps://doi.org/10.1017/neu.2013.44
dc.identifier.urihttps://hdl.handle.net/11468/16372
dc.identifier.volume26en_US
dc.identifier.wosWOS:000334123200007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofActa Neuropsychiatrica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSchizophreniaen_US
dc.subjectBipolar Disorderen_US
dc.subjectOxidative Metabolismen_US
dc.subjectOxidative Stressen_US
dc.subjectSchizoaffective Disorderen_US
dc.titleAre oxidative stress markers useful to distinguish schizoaffective disorder from schizophrenia and bipolar disorder?en_US
dc.titleAre oxidative stress markers useful to distinguish schizoaffective disorder from schizophrenia and bipolar disorder?
dc.typeArticleen_US

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