Serum Levels of Calcification Inhibitors in Patients With Intracerebral Hemorrhage

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dc.contributor.authorAcar, Abdullah
dc.contributor.authorCevik, Mehmet Ugur
dc.contributor.authorArikanoglu, Adalet
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorBasarili, Mustafa Kemal
dc.contributor.authorUzar, Ertugrul
dc.contributor.authorEkici, Faysal
dc.date.accessioned2024-04-24T17:20:25Z
dc.date.available2024-04-24T17:20:25Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe vascular calcification regulators and inflammatory markers including fetuin-A, osteopontin (OPN), and matrix Gla protein (MGP) may play an important role in the development of intracerebral hemorrhages (ICHs). So far, the relationship between these parameters and ICH has not been studied. Therefore, this study was designed to elucidate whether fetuin-A, MGP, and OPN are involved in the pathophysiology of ICH. The ICH group consisted of 27 consecutive patients with spontaneous ICH evaluated in the neurology intensive care unit within the first 24 hours from the onset of the stroke. The serum OPN levels were significantly increased in patients with ICH compared to the controls. On the other hand, the serum MGP and fetuin-A levels were significantly decreased in the patients with ICH in comparison to the controls. In the patients with ICH, the serum MGP levels of the nonsurvivors were statistically significantly lower than the MGP levels of the survivors. In conclusion, the change in serum fetuin-A, MGP, and OPN levels after ICH indicates that these parameters play a role in the pathophysiological processes leading to an ICH. Measurement of the serum MGP levels may also be of value to estimate mortality.en_US
dc.identifier.doi10.3109/00207454.2011.642039
dc.identifier.endpage232en_US
dc.identifier.issn0020-7454
dc.identifier.issn1563-5279
dc.identifier.issue5en_US
dc.identifier.pmid22115341
dc.identifier.scopus2-s2.0-84859404494
dc.identifier.scopusqualityQ2
dc.identifier.startpage227en_US
dc.identifier.urihttps://doi.org/10.3109/00207454.2011.642039
dc.identifier.urihttps://hdl.handle.net/11468/19035
dc.identifier.volume122en_US
dc.identifier.wosWOS:000302321600002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal of Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFetuin-Aen_US
dc.subjectIntracerebral Hemorrhageen_US
dc.subjectMortalityen_US
dc.subjectMatrix Gla Proteinen_US
dc.subjectOsteopontinen_US
dc.titleSerum Levels of Calcification Inhibitors in Patients With Intracerebral Hemorrhageen_US
dc.titleSerum Levels of Calcification Inhibitors in Patients With Intracerebral Hemorrhage
dc.typeArticleen_US

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