Evaluation of the Effect of Thymoquinone Treatment on Wound Healing in a Rat Burn Model

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dc.contributor.authorSelcuk, Caferi Tayyar
dc.contributor.authorDurgun, Mustafa
dc.contributor.authorTekin, Recep
dc.contributor.authorYolbas, Iyas
dc.contributor.authorBozkurt, Mehmet
dc.contributor.authorAkcay, Cemal
dc.contributor.authorAlabalik, Ulas
dc.date.accessioned2024-04-24T17:08:15Z
dc.date.available2024-04-24T17:08:15Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractThymoquinone (TQ) is a plant extract that has been shown to have antimicrobial, anti-inflammatory, and antioxidant effects. Because of these activities, the authors hypothesized that TQ would reduce inflammation and oxidative stress and accelerate wound closure in a rat model of deep second-degree burns. For the purposes of this study, 40 Sprague-Dawley rats were divided into five groups of eight rats each. Group 1 was the control group, group 2 was the silver sulfadiazine group, group 3 was treated with systemic TQ, group 4 received topical TQ, and group 5 was administered topical and systemic TQ. After the deep second-degree burn damage was created, daily dressing changes and TQ administration were continued in the study groups for a period of 21 days. Systemic TQ was administered intraperitoneally at a dose of 2 mg/kg/day, whereas the topical treatment was applied using a 0.5% solution. The changes in the wound site were observed macroscopically, histopathologically, microbiologically, and biochemically in all groups. The smallest necrotic areas were observed at the end of the study in the groups that were administered a combination of systemic and topical TQ, or solely topical TQ (6.1 +/- 1.6 cm(2) and 6.7 +/- 0.4 cm(2), respectively), whereas the largest necrotic areas were observed in the control group (11.2 +/- 1.2cm(2)). The total antioxidant state levels in the control group were significantly lower than in the other groups (P < .05), whereas the total oxidative stress levels were lower in the TQ groups compared with the control group (P < .05). The lowest bacterial counts were observed in the groups treated with both topical and systemic TQ (P < .05). TQ given systemically and/or topically reduced inflammation and oxidative stress and accelerated the rate of wound closure or reepithelialization.en_US
dc.identifier.doi10.1097/BCR.0b013e31827a2be1
dc.identifier.endpageE281en_US
dc.identifier.issn1559-047X
dc.identifier.issn1559-0488
dc.identifier.issue5en_US
dc.identifier.pmid23816998
dc.identifier.scopus2-s2.0-84885289788
dc.identifier.scopusqualityQ2
dc.identifier.startpageE274en_US
dc.identifier.urihttps://doi.org/10.1097/BCR.0b013e31827a2be1
dc.identifier.urihttps://hdl.handle.net/11468/17269
dc.identifier.volume34en_US
dc.identifier.wosWOS:000325705700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Burn Care & Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleEvaluation of the Effect of Thymoquinone Treatment on Wound Healing in a Rat Burn Modelen_US
dc.titleEvaluation of the Effect of Thymoquinone Treatment on Wound Healing in a Rat Burn Model
dc.typeArticleen_US

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