Protective effect of nebivolol on rat ovary exposed to deltamethrin toxicity

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dc.contributor.authorOtcu, Serap
dc.contributor.authorDeveci, Engin
dc.contributor.authorOzgokce, Cagdas
dc.contributor.authorGursoy, Goerkem Tutal
dc.contributor.authorTuncer, Mehmet Cudi
dc.date.accessioned2024-04-24T17:18:09Z
dc.date.available2024-04-24T17:18:09Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: We aimed to investigate the antioxidant activity of nebivolol against possible damage to the ovarian tissue due to the application of deltamethrin as a toxic agent, by evaluating histopathological proliferating cell nuclear antigen (PCNA) and tumor necrosis factor-alpha (TNF-alpha) signal molecules immunohistochemically. Methods: The animals were divided into three groups as control, deltamethrin and deltamethrin + nebivolol groups. Vaginal smears were taken after the animals were mated and detected on the first day of pregnancy. After the sixth day, deltamethrin (0.5 mL of 30 mg/kg BW undiluted ULV), and 2 mL of sterile nebivolol solution were administered intraperitoneally every day for 6-21 periods. After routine histopathological follow-up, the ovarian tissue was stained with hematoxylin and eosin stain. Results: Control group showed normal histology of ovarium. In deltamethrin group, hyperplasic cells, degenerative follicles, pyknotic nuclei, inflammation and hemorrhagic areas were observed. Nebivolol treatment restored these pathologies. Deltamethrin treatment increased TNF-alpha and PCNA reaction. However, nebivolol decreased the expression. Conclusion: It was thought that deltamethrin toxicity adversely affected follicle development by inducing degeneration and apoptotic process in preantral and antra follicle cells, and nebivolol administration might reduce inflammation and slow down the apoptotic signal in the nuclear phase and regulate reorganization.en_US
dc.identifier.doi10.1590/acb385423
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.pmid37878988
dc.identifier.scopus2-s2.0-85174956600
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1590/acb385423
dc.identifier.urihttps://hdl.handle.net/11468/18634
dc.identifier.volume38en_US
dc.identifier.wosWOS:001090070000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOvaryen_US
dc.subjectNebivololen_US
dc.subjectProliferating Cell Nuclear Antigenen_US
dc.subjectTumor Necrosis Factor-Alphaen_US
dc.titleProtective effect of nebivolol on rat ovary exposed to deltamethrin toxicityen_US
dc.titleProtective effect of nebivolol on rat ovary exposed to deltamethrin toxicity
dc.typeArticleen_US

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