Targeting novel antigens in the arterial wall in thromboangiitis obliterans

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dc.contributor.authorGuzel, Elif
dc.contributor.authorTopal, Ender
dc.contributor.authorYildirim, Ayse
dc.contributor.authorAtilla, Pergin
dc.contributor.authorAkkus, Murat
dc.contributor.authorDagdeviren, Attila
dc.date.accessioned2024-04-24T17:20:21Z
dc.date.available2024-04-24T17:20:21Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractThromboangiitis obliterans is an inflammatory disease possibly resulting from cigarette smoking as a primary etiologic factor, perhaps as a delayed type of hypersensitivity or toxic angiitis. As little is known about the pathogenesis of the disease, we aimed to determine novel antigens that might be responsible from the local inflammatory reactions and structural changes observed in this disease. An indirect immunoperoxidase technique is used to examine the tissue samples obtained from the dorsalis pedis artery of affected individuals with twenty monoclonal antibodies. Among these several antigens which are not previously reported in TAO like CD34, CD44 and CD90 were determined in the tissue samples examined. On the other hand, many other antigens like cytokine/chemokine receptors, several enzymes and leukocyte/lymphocyte antigens were lacking giving some clues about the local pathological reactions. We briefly discussed our findings for several critical antigens those first described in the present work, possibly having roles in the development of the disease. Expression of the CD90/CD11c receptor/ligand pair seems to play an important role in mononuclear cell recruitment to the damage site. Vascular invasion of not only tunica intima but also the tunica media in affected vessels is clearly demonstrated using endothelial cell specific antigens.en_US
dc.identifier.doi10.2478/v10042-008-0104-6
dc.identifier.endpage141en_US
dc.identifier.issn0239-8508
dc.identifier.issn1897-5631
dc.identifier.issue1en_US
dc.identifier.pmid20529829
dc.identifier.scopus2-s2.0-77954382382
dc.identifier.scopusqualityQ2
dc.identifier.startpage134en_US
dc.identifier.urihttps://doi.org/10.2478/v10042-008-0104-6
dc.identifier.urihttps://hdl.handle.net/11468/18960
dc.identifier.volume48en_US
dc.identifier.wosWOS:000282022700021
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofFolia Histochemica Et Cytobiologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThromboangiitis Obliteransen_US
dc.subjectTaoen_US
dc.subjectBuerger's Diseaseen_US
dc.subjectVasculitisen_US
dc.subjectImmunohistochemistryen_US
dc.subjectCd90en_US
dc.subjectCd11cen_US
dc.titleTargeting novel antigens in the arterial wall in thromboangiitis obliteransen_US
dc.titleTargeting novel antigens in the arterial wall in thromboangiitis obliterans
dc.typeArticleen_US

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