Serum malondialdehyde, coenzyme Q10 and 8-hydroxy-2-deoxyguanosine levels in calves with foot-and-mouth disease

Basit Öğe Kaydı
dc.authorid0000-0002-6034-3203en_US
dc.contributor.authorÖzkan, Cumali
dc.contributor.authorHuyut, Zübeyir
dc.contributor.authorYıldırım, Serkan
dc.contributor.authorÖzbek, Mustafa
dc.contributor.authorİçen, Hasan
dc.date.accessioned2022-08-10T07:44:28Z
dc.date.available2022-08-10T07:44:28Z
dc.date.issued2018en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Klinik Bilimler Bölümü, Cerrahi Ana Bilim Dalıen_US
dc.description.abstractFoot-and-mouth disease (FMD) is an acute, contagious viral disease in cattle that is associated with enormous economic losses in Turkey and worldwide. The purpose of this study was to determine changes in serum malondialdehyde (MDA), coenzyme Q10 (CoQIO), 8-hydroxy-2-deoxyguanosine (8-OHdG) and deoxyguanosine (dG) and to perform histopathological examinations in calves with FMD. Thirty calves were studied, 20 of which were infected with FMD and 10 were free of the disease. Following a routine clinical examination, blood samples were obtained, and serum MDA, CoQI O, 8-OHdG and dG levels were determined. Necropsy and histopathological examinations were performed on dead calves with FMD. MDA and 8-OHdG/106dG levels were significantly higher in calves with FMD than in the control group. However, the increase in CoQIO levels in calves with FMD, compared with the control group, was not statistically significant. Macroscopic examination of the heart tissue of calves with acute myocarditis revealed the presence of pale, yellowish gray-white necrotic muscle fibers in the ventricular wall of the heart. The muscle fibers in the myocardium were swollen and exhibited pyknotic nuclei and intense lymphocytic cell infiltration. In longitudinal sections, the muscle fibers were non-striated, swollen, and homogenously pink and contained pink nuclei. Between muscle fibers, intense mononuclear cell infiltration was observed. The findings of the present study indicate that oxidative stress is significantly increased in calves with FMD, and that oxidative DNA damage may play an important role in the etiopathogenesis of FMD. This is the first study to report CoQIO and 8-OHdG levels in calves with FMD, and its findings may serve as the basis for future studies on this subject.en_US
dc.identifier.citationÖzkan, C., Huyut, Z., Yıldırım, S., Özbek, M. ve İçen, H. (2018). Serum malondialdehyde, coenzyme Q10 and 8-hydroxy-2-deoxyguanosine levels in calves with foot-and-mouth disease. Medycyna Weterynaryjna, 74(11), 708-712.en_US
dc.identifier.doi10.21521/mw.6134
dc.identifier.endpage712en_US
dc.identifier.issn0025-8628
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-85058114478
dc.identifier.scopusqualityQ4
dc.identifier.startpage708en_US
dc.identifier.urihttp://www.medycynawet.edu.pl/archives/423/6134-summary-med-weter-74-10-6134-2020
dc.identifier.urihttps://hdl.handle.net/11468/10162
dc.identifier.volume74en_US
dc.identifier.wosWOS:000445878600007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorİçen, Hasan
dc.language.isoenen_US
dc.publisherPolskie Towarzystwo Nauk Weterynaryjnychen_US
dc.relation.ispartofMedycyna Weterynaryjna
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject8-OHdGen_US
dc.subjectCoQI Oen_US
dc.subjectFoot-and-mouth diseaseen_US
dc.subjectMDAen_US
dc.subjectMyocarditisen_US
dc.titleSerum malondialdehyde, coenzyme Q10 and 8-hydroxy-2-deoxyguanosine levels in calves with foot-and-mouth diseaseen_US
dc.titleSerum malondialdehyde, coenzyme Q10 and 8-hydroxy-2-deoxyguanosine levels in calves with foot-and-mouth disease
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Serum malondialdehyde, coenzyme Q10.pdf
Boyut:
951.77 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Klinik Bilimler Bölümü Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu