DNA damage and antioxidants in treatment naive children with obsessive-compulsive disorder

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dc.contributor.authorSimsek, Seref
dc.contributor.authorGencoglan, Salih
dc.contributor.authorYuksel, Tugba
dc.date.accessioned2024-04-24T16:18:18Z
dc.date.available2024-04-24T16:18:18Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe current study aimed to investigate whether serum antioxidant levels and DNA damage differ between the children and adolescents with Obsessive Compulsive Disorder (OCD) and healthy controls. The study included 31 children (Male/Female, 22/9; age range 7-17 years), with treatment naive OCD diagnosed according to Diagnostic and Statistical Manual of Mental Disorders-V (DSM-V) and 28 age- and gender-matched healthy control subjects. Children's Yale Brown Obsession Compulsion Scale (CY-BOC) was applied to the children. Glutathione peroxidase (GPx), superoxide dismutase (SOD), coenzyme Q (CoQ), and 8-Hydroxy-2-Deoxyguanosine (8-OHdG) were all measured by the enzyme-linked immunosorbent assay method. GPx, CoQ and 8-OHdG levels were found to be significantly higher in the OCD group, compared to the control group (p=0.010, p=0.034, p=0.010, respectively); however, no significant difference was found in the SOD levels between two groups (p=0.10). There were no correlations between the CY-BOC scores, depression scores, duration of the disease and biochemical parameters (p > 0.05, for all). Children with OCD were found to have higher antioxidant levels and oxidative DNA damage. The findings of this study support the role of oxidative stress in the pathogenesis of OCD. In this regard, any possible effect of adding antioxidants to conventional treatment can be investigated. (C) 2016 Published by Elsevier Ireland Ltd.en_US
dc.identifier.doi10.1016/j.psychres.2016.01.054
dc.identifier.endpage137en_US
dc.identifier.issn0165-1781
dc.identifier.pmid26833278
dc.identifier.scopus2-s2.0-84959200144
dc.identifier.scopusqualityQ1
dc.identifier.startpage133en_US
dc.identifier.urihttps://doi.org/10.1016/j.psychres.2016.01.054
dc.identifier.urihttps://hdl.handle.net/11468/15977
dc.identifier.volume237en_US
dc.identifier.wosWOS:000371939300022
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofPsychiatry Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObsessive Compulsive Disorderen_US
dc.subjectOxidative Stressen_US
dc.subjectAntioxidant Statusen_US
dc.subjectDna Damageen_US
dc.subjectChildrenen_US
dc.subjectAdolescentsen_US
dc.titleDNA damage and antioxidants in treatment naive children with obsessive-compulsive disorderen_US
dc.titleDNA damage and antioxidants in treatment naive children with obsessive-compulsive disorder
dc.typeArticleen_US

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