The prevalence of insulin resistance in nondiabetic nonobese patients with chronic kidney disease

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dc.contributor.authorSit, Dede
dc.contributor.authorKadiroglu, Ali Kemal
dc.contributor.authorKayabasi, Hasan
dc.contributor.authorYilmaz, M. Emin
dc.date.accessioned2024-04-24T15:59:39Z
dc.date.available2024-04-24T15:59:39Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study was undertaken to evaluate the prevalence of insulin resistance (IR) and associated factors in nondiabetic, nonobese patients with chronic kidney disease (CKD) who had not yet received dialysis therapy. A group of 89 consecutive patients (42 male, 47 female) who were hospitalized in the Nephrology Clinic at Dicle University, had recently been diagnosed with CKD, and had not yet been treated with dialysis were enrolled in the study, as was a control group of 30 healthy volunteers. Diabetic and obese patients were excluded. IR was determined by the homeostasis model assessment of IR (HOMA-IR) formula. Blood samples were taken after an overnight fasting period to establish serum glucose, insulin, C-peptide, albumin, lipid profile, hematocrit, bicarbonate, and intact parathormone (iPTH) levels. The mean age of patients was 48.7 +/- 19.7 y (men, 49.5 +/- 21.5 y; women, 48.1 +/- 18.0 y); other mean values were as follows: glucose, 98.4 +/- 20.6 mg/dL; insulin, 16.7 +/- 16.2 mu U/mL; HOMA-IR, 5.46 +/- 1.14; hemoglobin (Hgb), 8.7 +/- 1.6 g/dL; calcium-phosphorus product (Ca x P), 52.2 +/- 16.2 mg2/dL(2); WTH, 377.7 +/- 258.1 pg/mL, and bicarbonate (HCO3), 16.6 +/- 5.3 mEq/L. HOMA-IR was significantly higher in patients with stage 4 CKD than in controls (P <.001); serum levels of urea, creatinine clearance (CrCl), C-reactive protein (CRP), albumin, total cholesterol, high-density lipoprotein cholesterol (HDL-C), Hgb, HCO3, Ca x P, and WTH were found to be associated with HOMA-IR when a comparison was made with the control group. According to correlation analyses of possible risk factors in patients with IR, positive correlations with age, body mass index, CRP, Ca x P product, and WTH, and negative correlations with albumin, CrCl, Hgb, and HDL-C were found. A high percentage of IR was found, and this percentage increased as glomerular filtration rate decreased in patients with stage 4 CKD. In addition, a correlation was found between IR and parameters such as age, body mass index, CRP, Ca x P, iPTH, albumin, CrCl, Hgb, and HDL-C.en_US
dc.identifier.doi10.1007/BF02850219
dc.identifier.endpage998en_US
dc.identifier.issn0741-238X
dc.identifier.issn1865-8652
dc.identifier.issue6en_US
dc.identifier.pmid17276966
dc.identifier.scopus2-s2.0-33847395750
dc.identifier.scopusqualityQ1
dc.identifier.startpage988en_US
dc.identifier.urihttps://doi.org/10.1007/BF02850219
dc.identifier.urihttps://hdl.handle.net/11468/14192
dc.identifier.volume23en_US
dc.identifier.wosWOS:000244518100016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAdvances in Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Kidney Diseaseen_US
dc.subjectPredialytic Stageen_US
dc.subjectInsulin Resistanceen_US
dc.titleThe prevalence of insulin resistance in nondiabetic nonobese patients with chronic kidney diseaseen_US
dc.titleThe prevalence of insulin resistance in nondiabetic nonobese patients with chronic kidney disease
dc.typeArticleen_US

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