Evaluation of serum oxidant/antioxidant balance in multiple sclerosis

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dc.contributor.authorAcar, Abdullah
dc.contributor.authorCevik, M. Ugur
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorUzar, Ertugrul
dc.contributor.authorTamam, Yusuf
dc.contributor.authorArikanoglu, Adalet
dc.contributor.authorYucel, Yavuz
dc.date.accessioned2024-04-24T16:10:38Z
dc.date.available2024-04-24T16:10:38Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe total oxidative status (TOS)/total anti-oxidative status (TAS) ratio can provide information on an individual's absolute oxidative stress index (OSI). We investigated the alterations in the oxidant-antioxidant balance by measuring the oxidant parameters OSI, TOS, and malondialdehyde (MDA) together with the antioxidant parameters such as TAS, and superoxide dismutase (SOD) in patients with relapsing remitting multiple sclerosis (MS). To our knowledge, this is the first study to evaluate OSI in patients with relapsing remitting MS. 35 ambulatory patients with relapsing-remitting MS (35.8 +/- A 8.7 years) and 32 age- and activity-matched healthy control subjects (35.1 +/- A 3.7 years) that participated in the study. Serum TAS and TOS levels were determined using new automated methods. MS patients had higher concentrations of MDA (151.5 +/- A 51.1 vs. 111.3 +/- A 27.4 nmol/g protein, respectively; p < 0.001), TOS (148.1 +/- A 162.5 vs. 48.3 +/- A 46.4 mmol H2O2 Equiv./g protein, respectively; p = 0.002), OSI (21124 +/- A 32543 vs. 5294 +/- A 5562, respectively; p = 0.008), and SOD (4.5 +/- A 0.7 vs. 3.4 +/- A 0.6 U/L, respectively; p < 0.001) compared with healthy controls. On the other hand, MS patients had lower concentrations of NO (12.3 +/- A 6.9 vs. 17.4 +/- A 2.5 mu mol/g protein, respectively; p < 0.001) and TAS (0.82 +/- A 0.27 vs. 0.26 +/- A 0.15, respectively; p = 0.011) compared with healthy controls. In conclusion, these findings indicate that the oxidative stress plays an important role in the pathogenesis of MS.en_US
dc.description.sponsorshipResearch Foundation of Dicle Universityen_US
dc.description.sponsorshipThis research was part of a project that was financially supported by Research Foundation of Dicle University, so we are thankful for this support.en_US
dc.identifier.doi10.1007/s13760-012-0059-4
dc.identifier.endpage280en_US
dc.identifier.issn0300-9009
dc.identifier.issn2240-2993
dc.identifier.issue3en_US
dc.identifier.pmid22450709
dc.identifier.scopus2-s2.0-84866118114
dc.identifier.scopusqualityQ2
dc.identifier.startpage275en_US
dc.identifier.urihttps://doi.org/10.1007/s13760-012-0059-4
dc.identifier.urihttps://hdl.handle.net/11468/14978
dc.identifier.volume112en_US
dc.identifier.wosWOS:000308227300009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofActa Neurologica Belgica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultiple Sclerosisen_US
dc.subjectPathogenesisen_US
dc.subjectOxidative Stress Indexen_US
dc.subjectTotal Oxidant Statusen_US
dc.subjectTotal Antioxidant Statusen_US
dc.titleEvaluation of serum oxidant/antioxidant balance in multiple sclerosisen_US
dc.titleEvaluation of serum oxidant/antioxidant balance in multiple sclerosis
dc.typeArticleen_US

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