Expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in the endometrium of patients with repeated implantation failure after in vitro fertilization

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dc.contributor.authorTurgut, A.
dc.contributor.authorGoruk, N. Y.
dc.contributor.authorTunc, S. Y.
dc.contributor.authorAgaçayak, E.
dc.contributor.authorAlabalik, U.
dc.contributor.authorYalinkaya, A.
dc.contributor.authorGul, T.
dc.date.accessioned2024-04-24T17:33:56Z
dc.date.available2024-04-24T17:33:56Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractAIM: To compare the immunohistochemical expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in repeated implantation failure (RIF) patients with normal fertile controls. PATIENTS AND METHODS: The study group consisted of primary infertile patients with RIF and normal fertile controls between January 2011 and February 2013. Endometrial samples received at the luteal phase were exposed to immunohistochemical staining for EMMPRIN antibodies. EMMPRIN expression of endometrial glandular epithelial cells, stromal cells and vascular endothelial cells were evaluated. The main outcome measure was defined as immunohistochemical score with regard to the severity and extent of staining. RESULTS: The study group consisted of 26 primary infertile patients, whereas the control group consisted of 40 normal fertile controls. The fertile group was found to have stronger expression of EMMPRIN than the study group when endometrial glandular epithelial cells, stromal cells and vascular endothelial cells were evaluated with regards to the severity of staining (p < 0.001), the extent of staining (p < 0.001) and total staining score (p < 0.001). CONCLUSIONS: This is the first study showing low expression of EMMPRIN in the endometrial cells of the patients with RIF compared with fertile healthy controls. We suggest that reduced EMMPRIN expression in the human endometrium may lead to poor endometrial receptivity.en_US
dc.identifier.endpage280en_US
dc.identifier.issn1128-3602
dc.identifier.issue2en_US
dc.identifier.pmid24488920
dc.identifier.scopus2-s2.0-84896943501
dc.identifier.scopusqualityQ2
dc.identifier.startpage275en_US
dc.identifier.urihttps://hdl.handle.net/11468/20892
dc.identifier.volume18en_US
dc.identifier.wosWOS:000331437400021
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndometriumen_US
dc.subjectIn Vitro Fertilizationen_US
dc.subjectRepeated Implantation Failureen_US
dc.subjectEndometrial Receptivityen_US
dc.subjectEmmprinen_US
dc.titleExpression of extracellular matrix metalloproteinase inducer (EMMPRIN) in the endometrium of patients with repeated implantation failure after in vitro fertilizationen_US
dc.titleExpression of extracellular matrix metalloproteinase inducer (EMMPRIN) in the endometrium of patients with repeated implantation failure after in vitro fertilization
dc.typeArticleen_US

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