Effects of enoxaparin and rivaroxaban on tissue survival in skin degloving injury: an experimental study

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dc.contributor.authorAzboy, Ibrahim
dc.contributor.authorDemirtas, Abdullah
dc.contributor.authorBulut, Mehmet
dc.contributor.authorAlabalik, Ulas
dc.contributor.authorUcar, Yavuz
dc.contributor.authorAlemdar, Celil
dc.date.accessioned2024-04-24T17:24:08Z
dc.date.available2024-04-24T17:24:08Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to evaluate the effects of the antithrombotic agents enoxaparin, and rivaroxaban on tissue survival following skin degloving injury in an experimental rat tail model. Methods: The study included 24 rats divided into three equal groups of 8; the enoxaparin group (Group 1), the rivaroxaban group (Group 2) and the saline control group (Group 3). A degloving injury was created by making a circular incision 5 cm distal to the base of the tail; manual traction was applied to the tail skin distal to the incision. After 15 minutes, the ends of the incision were sutured back in place. Antithrombotic agents were administered immediately after suturing and repeated once a day for 15 days. At the end of Day 15, the experiment was terminated. Gross morphological tissue survival and histopathology were evaluated. Results: Histopathological examination of the enoxaparin and rivaroxaban groups revealed that the skin was mostly normal or intact with minimal inflammation. The mean length of necrotic area was significantly higher in the saline group compared to the enoxaparin and rivaroxaban groups (p < 0.05). No statistically significant differences were noted between the rivaroxaban and enoxaparin groups (p=0.451). The mean extent of skin necrosis was significantly higher in the control group than the study groups (p < 0.05), while there was no significant difference in the length of necrotic area between Group 1 and 2 (p=0.722). Conclusion: Rivaroxaban and enoxaparin improved tissue survival in skin degloving injuries in terms of gross morphological and histopathological findings in a rat tail model.en_US
dc.identifier.doi10.3944/AOTT.2014.13.0075
dc.identifier.endpage216en_US
dc.identifier.issn1017-995X
dc.identifier.issue2en_US
dc.identifier.pmid24747632
dc.identifier.startpage212en_US
dc.identifier.trdizinid158645
dc.identifier.urihttps://doi.org/10.3944/AOTT.2014.13.0075
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/158645
dc.identifier.urihttps://hdl.handle.net/11468/19439
dc.identifier.volume48en_US
dc.identifier.wosWOS:000335199800018
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTurkish Assoc Orthopaedics Traumatologyen_US
dc.relation.ispartofActa Orthopaedica Et Traumatologica Turcica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDegloving Injuryen_US
dc.subjectEnoxaparinen_US
dc.subjectRaten_US
dc.subjectRivaroxabanen_US
dc.subjectTissue Survivalen_US
dc.titleEffects of enoxaparin and rivaroxaban on tissue survival in skin degloving injury: an experimental studyen_US
dc.titleEffects of enoxaparin and rivaroxaban on tissue survival in skin degloving injury: an experimental study
dc.typeArticleen_US

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