LC-ESI-MS/MS analysis of phenolic compounds and in vitro cytotoxicity and apoptosis-inducing effects of Nonea pulmonarioides extracts

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dc.contributor.authorAbdullah, Fuad O.
dc.contributor.authorMuhammad, Haval H.
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorÇakır, Oğuz
dc.contributor.authorTarhan, Abbas
dc.date.accessioned2024-04-24T17:07:48Z
dc.date.available2024-04-24T17:07:48Z
dc.date.issued2024
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractThe chemical composition of Nonea pulmonarioides extracts were investigated for the first time. The phytoconstituents of the methanol extracts were screened by using LC/MS-MS technique. The anticancer activity of the acetone and methanol extracts were measured against four cancer cell lines; MCF-7, PC3, HT-29, and U-87 MG. Thirty phenolic compounds were identified, rosmarinic (90.06 mg analyte/g extract) and fumaric acids (39.737 mg analyte/g extract) were major compounds of the studied species. Moreover, both methanol and acetone extracts were found to have strong anticancer activities. The acetone extract HT-29 (with IC50 of 10.17 +/- 0.25 mu g/mL) compared with standard cis-platin (with IC50 of 22.20 +/- 0.72 mu g/mL) with apoptotic mediated programmed cell death. These findings identified N. pulmonarioides as a potential species exhibiting anticancer properties. In conclusion, the compelling results show that the methanol extract contains possible bioactive compounds with anticancer properties that require isolation and further characterisation. [GRAPHICS] .en_US
dc.description.sponsorshipSalahaddin University-Erbilen_US
dc.description.sponsorshipThe author is grateful to Salahaddin University-Erbil for the support researchersen_US
dc.identifier.citationAbdullah, F. O., Muhammad, H. H., Yılmaz, M. A., Çakır, O. ve Tarhan, A. (2024). LC-ESI-MS/MS analysis of phenolic compounds and in vitro cytotoxicity and apoptosis-inducing effects of Nonea pulmonarioides extracts. Natural Product Research, 1-8.
dc.identifier.doi10.1080/14786419.2024.2306914
dc.identifier.issn1478-6419
dc.identifier.issn1478-6427
dc.identifier.pmid38263864
dc.identifier.scopus2-s2.0-85182997665
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1080/14786419.2024.2306914
dc.identifier.urihttps://hdl.handle.net/11468/17001
dc.identifier.wosWOS:001150003900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNatural Product Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMicrowave extractionen_US
dc.subjectAnalytical method validationen_US
dc.subjectLc-Ms/Msen_US
dc.subjectRosmarinic aciden_US
dc.subjectFumaric aciden_US
dc.subjectCytotoxicityen_US
dc.subjectApoptosisen_US
dc.titleLC-ESI-MS/MS analysis of phenolic compounds and in vitro cytotoxicity and apoptosis-inducing effects of Nonea pulmonarioides extractsen_US
dc.titleLC-ESI-MS/MS analysis of phenolic compounds and in vitro cytotoxicity and apoptosis-inducing effects of Nonea pulmonarioides extracts
dc.typeArticleen_US

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