Cytokines and depression in cases with fibromyalgia

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dc.contributor.authorGür, A
dc.contributor.authorKarakoç, M
dc.contributor.authorNas, K
dc.contributor.authorÇevik, R
dc.contributor.authorDenli, A
dc.contributor.authorSaraç, J
dc.date.accessioned2024-04-24T17:33:26Z
dc.date.available2024-04-24T17:33:26Z
dc.date.issued2002
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective. Fibromyalgia (FM) is a chronic, painful musculoskeletal disorder characterized by widespread pain, pressure, hyperalgesia, morning stiffness, and an increased incidence of depressive symptoms, The etiology, however, has remained elusive. The aim of the present study was to examine the inflammatory response system in FM and to investigate the effect of depression level on serum cytokines. Methods. Serum interleukin-1 (IL-1), IL-2 receptor (IL-2r), IL-6, and IL-8 and the Hamilton Depression Rating Scale (HDRS) score were determined in 32 healthy volunteers and in 81 patients with FM, classified according to the American College of Rheumatology criteria. Results. In our study, serum IL-1 and IL-6 were not statistically significant, but serum IL-8, IL2r, and HDRS score were significantly higher in patients with FM than the control group (p < 0.01). In addition, in patients with FM, IL-8 was found to be related to pain intensity (r = 0.35; p < 0,01). Conclusion. IL-8 may play an important role in the occurrence of pain in FM.en_US
dc.identifier.endpage361en_US
dc.identifier.issn0315-162X
dc.identifier.issn1499-2752
dc.identifier.issue2en_US
dc.identifier.pmid11838856
dc.identifier.scopus2-s2.0-0036163288
dc.identifier.scopusqualityQ2
dc.identifier.startpage358en_US
dc.identifier.urihttps://hdl.handle.net/11468/20689
dc.identifier.volume29en_US
dc.identifier.wosWOS:000173618300027
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherJ Rheumatol Publ Coen_US
dc.relation.ispartofJournal of Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytokinesen_US
dc.subjectDepressionen_US
dc.subjectFibromyalgiaen_US
dc.titleCytokines and depression in cases with fibromyalgiaen_US
dc.titleCytokines and depression in cases with fibromyalgia
dc.typeArticleen_US

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