Evaluation of the Vasoplegic impact of Papaverine in the rat aorta

Basit Öğe Kaydı
dc.contributor.authorYavuz, Celal
dc.contributor.authorCallskan, Ahmet
dc.contributor.authorKarahan, Oguz
dc.contributor.authorDemirtas, Sinan
dc.contributor.authorYazici, Suleyman
dc.contributor.authorGuclu, Orkut
dc.contributor.authorDonmez, Soner
dc.date.accessioned2024-04-24T17:33:54Z
dc.date.available2024-04-24T17:33:54Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To identify the degree of vasoplegic affinity of papaverine to rat thoracic aortas following constriction caused by adrenalin, serotonin and potassium chloride in an in-vitro model. Methods: The in vitro vasoplegic efficacy of papaverine against adrenalin (10(-5) M), serotonin (5HT) (10(-4) M), and KCI (60 mM) was assessed, using a rat aortic vasospasm model in an organ bath. First, aortic rings were constricted with a submaximal dose of vasoconstrictor agents. The samples were then incubated with papaverine (3x10(-4) M) for 20 minutes, followed by readministration of the same vasoconstrictor agents. The first vasospastic response (before papaverine incubation) and the new vasoconstrictor responses (after papaverine incubation) of the vessels were then compared. Results: The vasoplegic effect of vasoconstrictor agents in decreasing order was observed as adrenalin>KCI>5HT. This different affinity for the vasoplegic effect is considered to be a temporary impact of the drugs and the maximal inhibition of vasoconstriction was detected for the adrenalin receptor. Conclusion: The relevance of the macromolecules is responsible for the permanent efficacy of the drugs. Different degrees of vasoconstriction were also obtained after papaverine administration, which suggests that different responses can occur as a result of different stimulation of receptor modulators.en_US
dc.identifier.endpage663en_US
dc.identifier.issn0030-9982
dc.identifier.issue6en_US
dc.identifier.pmid25252485
dc.identifier.scopus2-s2.0-84901671202
dc.identifier.scopusqualityQ3
dc.identifier.startpage660en_US
dc.identifier.urihttps://hdl.handle.net/11468/20883
dc.identifier.volume64en_US
dc.identifier.wosWOS:000336868300011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPakistan Medical Assocen_US
dc.relation.ispartofJournal of The Pakistan Medical Association
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPapaverinen_US
dc.subjectVasoplegic Effecten_US
dc.subjectVasoconstrictor Agentsen_US
dc.titleEvaluation of the Vasoplegic impact of Papaverine in the rat aortaen_US
dc.titleEvaluation of the Vasoplegic impact of Papaverine in the rat aorta
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu