Relationship between lentin, insulin resistance, insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with chronic kidney disease

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dc.contributor.authorAtamer, A.
dc.contributor.authorEcder, S. Alisir
dc.contributor.authorAkkus, Z.
dc.contributor.authorKocyigit, Y.
dc.contributor.authorAtamer, Y.
dc.contributor.authorIlhan, N.
dc.contributor.authorEcder, T.
dc.date.accessioned2024-04-24T17:14:43Z
dc.date.available2024-04-24T17:14:43Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study examined the relationship between leptin, insulin-like growth factor-1 (IGF-1), IGF binding protein-3 (IGFBP-3) and insulin resistance in patients with chronic kidney disease (CKD). Levels of leptin, insulin, IGF-1, IGFBP-3 and common routine parameters were measured in 45 patients (23 males and 22 females) with CKD and 45 healthy controls matched for age, gender and body mass index. IGF-1 and IGFBP-3 levels were measured using a two-site immunoradiometric assay. Leptin levels were measured using an enzyme-linked immunosorbent assay. A homeostasis model assessment computer-solved model was used to assess insulin resistance (HOMA-IR). Levels of serum leptin, insulin, IGF-1, IGFBP-3 and HOMA-IR were significantly increased in patients with CKD compared with healthy subjects, whereas fasting blood glucose was not significantly different between the two groups. In patients with CKD, the serum leptin level was significantly correlated with IGF-1, IGFBP-3 and HOMA-IR. In conclusion, this study suggests that there is an interaction between leptin, IGF-1, IGFBP-3 and insulin resistance in patients with CKD.en_US
dc.identifier.doi10.1177/147323000803600317
dc.identifier.endpage528en_US
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.issue3en_US
dc.identifier.pmid18534134
dc.identifier.scopus2-s2.0-45149126674
dc.identifier.scopusqualityQ2
dc.identifier.startpage522en_US
dc.identifier.urihttps://doi.org/10.1177/147323000803600317
dc.identifier.urihttps://hdl.handle.net/11468/18153
dc.identifier.volume36en_US
dc.identifier.wosWOS:000256373900017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of International Medical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Kidney Diseaseen_US
dc.subjectLeptinen_US
dc.subjectInsulin Resistanceen_US
dc.subjectInsulin-Like Growth Factor-1en_US
dc.subjectInsulin-Like Growth Factor Binding Protein-3en_US
dc.titleRelationship between lentin, insulin resistance, insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with chronic kidney diseaseen_US
dc.titleRelationship between lentin, insulin resistance, insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with chronic kidney disease
dc.typeArticleen_US

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