Efficacy of N-Acetylcysteine on Wound Healing of Nasal Mucosa

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dc.contributor.authorYilmaz, Beyhan
dc.contributor.authorTurkcu, Gul
dc.contributor.authorSengul, Engin
dc.contributor.authorGul, Aylin
dc.contributor.authorOzkurt, Fazil Emre
dc.contributor.authorAkdag, Mehmet
dc.date.accessioned2024-04-24T17:08:30Z
dc.date.available2024-04-24T17:08:30Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractPostoperative nasal mucosa healing is a highly complex and organized process, and the success rates of endoscopic sinus surgery and septoplasty surgeries are closely associated with the postoperative wound healing processes. In this experimental study, the authors' aim was to use histopathologic examination to investigate the effects of N-Acetylcysteine (NAC) on the wound healing of rat nasal mucosa after mechanical trauma. Twenty-one Sprague-Dawley rats were randomly divided into 3 groups: the nontreated group (N = 7), the control saline group (N = 7), and the NAC group (N = 7). No treatment was given to the nontreated group for 15 days. The control saline group received intraperitoneal injection of saline (2.5 mL/kg, intraperitoneal) for 15 days and the NAC group was intraperitoneally injected with NAC at a dose of 300 mg/kg/day for 15 days. At the beginning of the study, unilateral mechanical nasal trauma was induced with an interdental brush inserted through the right nostril in all rats. Samples were stained using hematoxylin and eosin solution, and were examined by a pathologist using a light microscope. The severity of inflammation was milder in the NAC group compared with that in the nontreated and saline groups (P < 0.05). The subepithelial thickness index was lower in the experimental group (P < 0.05). Goblet cell loss was reduced in the experimental group compared with the nontreated and saline groups (P < 0.05). NAC decreases inflammation and goblet cell loss. Therefore, NAC has potential beneficial effects on the wound healing of nasal mucosa in rats.en_US
dc.identifier.doi10.1097/SCS.0000000000001880
dc.identifier.endpageE426en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue5en_US
dc.identifier.pmid26091056
dc.identifier.scopus2-s2.0-84965141780
dc.identifier.scopusqualityQ3
dc.identifier.startpageE422en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000001880
dc.identifier.urihttps://hdl.handle.net/11468/17361
dc.identifier.volume26en_US
dc.identifier.wosWOS:000369611000018
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Craniofacial Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Acetylcysteineen_US
dc.subjectNasal Mucosaen_US
dc.subjectWound Healingen_US
dc.titleEfficacy of N-Acetylcysteine on Wound Healing of Nasal Mucosaen_US
dc.titleEfficacy of N-Acetylcysteine on Wound Healing of Nasal Mucosa
dc.typeArticleen_US

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