Protective Effect of Cordycepin on Experimental Testicular Ischemia/Reperfusion Injury in Rats

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dc.contributor.authorOkur, Mehmet Hanifi
dc.contributor.authorArslan, Serkan
dc.contributor.authorAydogdu, Bahattin
dc.contributor.authorZeytun, Hikmet
dc.contributor.authorBasuguy, Erol
dc.contributor.authorArslan, Mehmet Serif
dc.contributor.authorIbiloglu, Ibrahim
dc.date.accessioned2024-04-24T16:24:40Z
dc.date.available2024-04-24T16:24:40Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To investigate the role of cordycepin in testicular ischemia/reperfusion injury in rats. Materials and methods: Forty Wistar albino rats were randomly divided into four groups, as follows: group one, control (C); group two, torsion and ischemia (I); group three: detorsion with ischemia-reperfusion (IR); and group four, detorsion/cordycepin. The rats were then analyzed macromorphologically and histopathologically, and blood tests were performed. Specifically, the total oxidant status (TOS) and total antioxidant status (TAS) were determined, and malondialdehyde (MDA), tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1 beta levels were analyzed. In addition, pyknotic nuclei, spermatozoa, edema, and hemorrhage were assessed. Results: When the IR and cordycepin groups were compared with the other groups, there was a statistically significant decrease in TNF-alpha and MDA levels (p < 0.05). Increased TAS levels were observed in the cordycepin group compared with the control group. TOS levels were significantly increased in the I and IR groups, but decreased in the cordycepin group (p < 0.05). Similar effects were observed in tissue biochemistry analysis. Histopathological evaluations revealed that the spermatozoa count was decreased in the I and IR groups. However, there was an increase in the cordycepin group, as well as a statistically significant difference between the IR and cordycepin groups (p < 0.01). Finally, edema and inflammation were increased in the I and IR groups, but decreased in the cordycepin group. Conclusions: Histological and biochemical findings revealed that cordycepin protected against IR-induced testicular injury.en_US
dc.description.sponsorshipDicle University [14-TF-43]en_US
dc.description.sponsorshipThis study was supported by Scientific Research and Project Coordinator (DUBAP, 14-TF-43) in Dicle University.en_US
dc.identifier.doi10.1080/08941939.2016.1246629
dc.identifier.endpage8en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue1en_US
dc.identifier.pmid28402715
dc.identifier.scopus2-s2.0-85017409154
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1080/08941939.2016.1246629
dc.identifier.urihttps://hdl.handle.net/11468/16809
dc.identifier.volume31en_US
dc.identifier.wosWOS:000427276600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Investigative Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTestisen_US
dc.subjectIschemia/Reperfusionen_US
dc.subjectCordycepinen_US
dc.subjectTorsionen_US
dc.subjectCytokinesen_US
dc.subjectRaten_US
dc.titleProtective Effect of Cordycepin on Experimental Testicular Ischemia/Reperfusion Injury in Ratsen_US
dc.titleProtective Effect of Cordycepin on Experimental Testicular Ischemia/Reperfusion Injury in Rats
dc.typeArticleen_US

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