A transient early HBV-DNA increase during PEG-IFN? therapy of hepatitis D indicates loss of infected cells and is associated with HDV-RNA and HBsAg reduction

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dc.contributor.authorAnastasiou, Olympia E.
dc.contributor.authorYurdaydin, Cihan
dc.contributor.authorMaasoumy, Benjamin
dc.contributor.authorHardtke, Svenja
dc.contributor.authorCaruntu, Florin Alexandru
dc.contributor.authorCurescu, Manuela G.
dc.contributor.authorYalcin, Kendal
dc.date.accessioned2024-04-24T17:11:46Z
dc.date.available2024-04-24T17:11:46Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractHBV-DNA levels are low or even undetectable in the majority HDV-infected patients. The impact of PEG-IFN alpha on HBV-DNA kinetics in HDV-infected patients has not been studied in detail. We analysed data of a prospective treatment trial where 120 HDV-RNA-positive patients were randomized to receive PEG-IFN alpha-2a plus tenofovir-disoproxil-fumarate (PEG-IFN alpha/TDF, n = 59) or placebo (PEG-IFN alpha/PBO; n = 61) for 96 weeks. At week 96, HBV-DNA was still quantifiable in 71% of PEG-IFN alpha/PBO-treated patients but also in 76% of PEG-IFN alpha/TDF-treated patients, despite low HBV-DNA baseline values. Surprisingly, a transient HBV-DNA increase between weeks 12 and 36 was observed in 12 in PEG-IFN alpha/TDF-treated and 12 PEG-IFN alpha/PBO-treated patients. This increase was positively associated with HBsAg loss [(P = 0.049, odds ratio (OR) 5.1] and HDV-RNA suppression (P = 0.007, OR 4.1) at week 96. Biochemical markers of cell death (M30 and ALT) were higher during the HBV-DNA peak but no distinct systemic immune pattern could be observed by screening 91 soluble inflammatory markers. In conclusion, an early increase in HBV-DNA during PEG-IFN alpha-2a therapy occurred in more than 20% of patients, even in TDF-treated patients. This transient HBV-DNA rise may indicate PEG-IFN alpha-induced cell death and lead to long-term HDV-RNA suppression and HBsAg loss.en_US
dc.description.sponsorshipHepNet Study-House (German Liver Foundation); HepNet Study-House (German Ministry for Education and Research); HepNet Study-House (German Center for Infection Research); German Center for Infection Research [05.807]; University Duisburg-Essen; Hoffmann-La Roche; Gilead Sciencesen_US
dc.description.sponsorshipThe study was supported by the HepNet Study-House (a project of the German Liver Foundation founded by the German Liver Foundation, the German Ministry for Education and Research, and the German Center for Infectious Disease Research), the German Center for Infection Research (project 05.807), internal funds of the University Duisburg-Essen, Hoffmann-La Roche and Gilead Sciences.en_US
dc.identifier.doi10.1111/jvh.13439
dc.identifier.endpage419en_US
dc.identifier.issn1352-0504
dc.identifier.issn1365-2893
dc.identifier.issue2en_US
dc.identifier.pmid33185325
dc.identifier.scopus2-s2.0-85097415279
dc.identifier.scopusqualityQ2
dc.identifier.startpage410en_US
dc.identifier.urihttps://doi.org/10.1111/jvh.13439
dc.identifier.urihttps://hdl.handle.net/11468/17713
dc.identifier.volume28en_US
dc.identifier.wosWOS:000597760100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Viral Hepatitis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHbven_US
dc.subjectHdven_US
dc.subjectHepatitis Ben_US
dc.subjectHepatitis Den_US
dc.subjectInterferonen_US
dc.subjectViral Kineticsen_US
dc.titleA transient early HBV-DNA increase during PEG-IFN? therapy of hepatitis D indicates loss of infected cells and is associated with HDV-RNA and HBsAg reductionen_US
dc.titleA transient early HBV-DNA increase during PEG-IFN? therapy of hepatitis D indicates loss of infected cells and is associated with HDV-RNA and HBsAg reduction
dc.typeArticleen_US

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