Bleeding risk in patients with acute coronary syndrome in a Turkish population: Results from the Turkish Acute Coronary Syndrome Registry (TACSER) study

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dc.contributor.authorAvci, Eyup
dc.contributor.authorKiris, Tuncay
dc.contributor.authorAkgun, Didar Elif
dc.contributor.authorCelik, Aykan
dc.contributor.authorAkcay, Filiz Akyildiz
dc.contributor.authorAcar, Burak
dc.contributor.authorKurmus, Ozge
dc.date.accessioned2024-04-24T17:11:27Z
dc.date.available2024-04-24T17:11:27Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective Bleeding is one of the most important causes of mortality in patients with acute coronary syndrome (ACS). This study therefore aimed to investigate bleeding risk in patients with ACS who were scheduled to receive dual antiplatelet therapy (DAPT) in Turkey. Methods This was a multicentre, observational, cross-sectional cohort study. The study population included 963 patients with ACS from 12 centres in Turkey. We used the Predicting Bleeding Complication in Patients Undergoing Stent Implantation and Subsequent Dual Antiplatelet Therapy (PRECISE-DAPT) score to predict the bleeding risk for all the patients. The patients were divided into high (>= 25) or low (<25) bleeding risk groups based on their PRECISE-DAPT scores. Results The mean PRECISE-DAPT score was 21.9. Overall, 32.2% of the patients had high PRECISE-DAPT scores (>= 25). Compared with the male patients, the female patients had higher PRECISE-DAPT scores (28.2 +/- 15.7 vs 18.4 +/- 13.6,P < .001). Among the females, the rate of patients with a PRECISE-DAPT score >= 25 was 53%, while among the male patients, the score occurred at a rate of 22%. The female patients had lower haemoglobin (Hb) levels than the male patients (12.1 +/- 1.7 vs 13.8 +/- 1.9,P < .001) and lower creatinine clearance (70.7 +/- 27.5 vs 88.7 +/- 26.3,P < .001). The in-hospital bleeding rates were higher among the patients with high PRECISE-DAPT scores than among those who did not have high scores. Furthermore, the patients with high PRECISE-DAPT scores had a higher in-hospital mortality rate compared with those with low PRECISE-DAPT scores (1% vs 0%,P = .11). Conclusions The mean PRECISE-DAPT score was high among the patients with ACS in this study, indicating that the bleeding tendency was high. This study showed that the PRECISE-DAPT score may help physicians determine the type and duration of DAPT, especially in patients with ACS in Turkey.en_US
dc.identifier.doi10.1111/eci.13271
dc.identifier.issn0014-2972
dc.identifier.issn1365-2362
dc.identifier.issue11en_US
dc.identifier.pmid32592511
dc.identifier.scopus2-s2.0-85087161547
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/eci.13271
dc.identifier.urihttps://hdl.handle.net/11468/17529
dc.identifier.volume50en_US
dc.identifier.wosWOS:000543543600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEuropean Journal of Clinical Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Coronary Syndromeen_US
dc.subjectDual Antiplatelet Therapyen_US
dc.subjectPrecise-Dapt Scoreen_US
dc.titleBleeding risk in patients with acute coronary syndrome in a Turkish population: Results from the Turkish Acute Coronary Syndrome Registry (TACSER) studyen_US
dc.titleBleeding risk in patients with acute coronary syndrome in a Turkish population: Results from the Turkish Acute Coronary Syndrome Registry (TACSER) study
dc.typeArticleen_US

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