Histological investigation of the impact of streptozotocin-induced experimental diabetes on the healthy gingivae of rats

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dc.contributor.authorDag, Ahmet
dc.contributor.authorFirat, Ela Tules
dc.contributor.authorUysal, Ersin
dc.contributor.authorKetani, Sennur
dc.contributor.authorKetani, Muzaffer Aydin
dc.date.accessioned2024-04-24T17:07:45Z
dc.date.available2024-04-24T17:07:45Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study was aimed at the histological investigation of the impact of experimental diabetes on the healthy gingiva of rats. Thirty male Wistar rats were used in this study. The animals were randomly divided into two groups (n = 15) prior to the experiment. Group 1 experimental diabetes was created by streptozotocin injection in 15 rats. Group 2 comprised the control group (15 rats). On the 7th, 14th and 21st days after the induction of diabetes by streptozotocin, five animals from each group were euthanized by cardiac puncture. The gingiva of the maxillary left first molar tooth of the sacrificed animals was extracted for histological examination. Histological examination demonstrated that, when compared to the control group, the diabetes group displayed marked hyperkeratosis and parakeratosis of the gingival epithelium on day 21 post-induction. Furthermore, the diabetes group presented with an increased number of inflammatory cells and vasodilatation of the capillaries, in comparison to the controls. The overall evaluation of the findings obtained in this study suggested that diabetes alone could cause changes in the periodontium and affect periodontal health.en_US
dc.identifier.doi10.1080/13102818.2014.943558
dc.identifier.endpage715en_US
dc.identifier.issn1310-2818
dc.identifier.issn1314-3530
dc.identifier.issue4en_US
dc.identifier.pmid26740771
dc.identifier.scopus2-s2.0-84910100482
dc.identifier.scopusqualityQ3
dc.identifier.startpage710en_US
dc.identifier.urihttps://doi.org/10.1080/13102818.2014.943558
dc.identifier.urihttps://hdl.handle.net/11468/16946
dc.identifier.volume28en_US
dc.identifier.wosWOS:000348934100017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnology & Biotechnological Equipment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectExperimental Diabetesen_US
dc.subjectThe Histological Investigationen_US
dc.subjectGingiva Of Ratsen_US
dc.titleHistological investigation of the impact of streptozotocin-induced experimental diabetes on the healthy gingivae of ratsen_US
dc.titleHistological investigation of the impact of streptozotocin-induced experimental diabetes on the healthy gingivae of rats
dc.typeArticleen_US

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