The expression of epidermal growth factor receptors and their ligands (epidermal growth factor, neuregulin, amphiregulin) in the bitch uterus during the estrus cycle

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dc.contributor.authorSagsoz, Hakan
dc.contributor.authorLiman, Narin
dc.contributor.authorSaruhan, Berna Guney
dc.contributor.authorKucukaslan, Ibrahim
dc.date.accessioned2024-04-24T16:10:49Z
dc.date.available2024-04-24T16:10:49Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn order to study the possible role of EGFR receptors in the bitch reproductive process, we have analyzed the expression pattern and localization of EGFR receptors and some of their ligands epidermal growth factor (EGF), neuregulin (NRG), amphiregulin (AREG), in the uterus during the estrus cycle using immunohistochemistry. The immunostaining for receptors and ligands of EGFR/ligand system was confined to membrane and cytoplasm of the target cells. Variations were observed, not only at the different stages of the estrous cycle, but also in the different tissue compartments of the uterus. However, it was detected that the immunostainings for NRG and AREG in the different cells do not show important differences at stages of the estrus cycle. In the luminal epithelium, strong immunostaining for ErbB1/HER1, ErbB2/HER2, ErbB4/HER4 and EGF was found at estrus. In the glandular epithelium, strong immunostaining for ErbB4/HER4 was observed at diestrus, while strong immunostaining for EGF was detected in both of estrus and diestrus. ErbB3/HER3 immunoreactivity in the stromal cells was higher at diestrus and anestrus, while ErbB4/HER4 immunoreactivity was lower at anestrus. In the myometrium, the highest levels of immunoreactivity of ErbB2/HER2 were found at estrus, while ErbB3/HER3 immunoreactivity was higher at anestrus. EGF immunoreactivity was lower at anestrus compared to other stage of cycle. Altered EGFR/ligand system expression during the estrus cycle suggests this growth factor system is a potent regulator of proliferation and differentiation events during preparation for implantation of bitch uterus. (C) 2014 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.anireprosci.2014.04.005
dc.identifier.endpage179en_US
dc.identifier.issn0378-4320
dc.identifier.issn1873-2232
dc.identifier.issue3-4en_US
dc.identifier.pmid24813021
dc.identifier.scopus2-s2.0-84901618772
dc.identifier.scopusqualityQ1
dc.identifier.startpage161en_US
dc.identifier.urihttps://doi.org/10.1016/j.anireprosci.2014.04.005
dc.identifier.urihttps://hdl.handle.net/11468/15125
dc.identifier.volume147en_US
dc.identifier.wosWOS:000337982500010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofAnimal Reproduction Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndometriumen_US
dc.subjectErbben_US
dc.subjectAregen_US
dc.subjectNrgen_US
dc.subjectEstrusen_US
dc.subjectDiestrusen_US
dc.titleThe expression of epidermal growth factor receptors and their ligands (epidermal growth factor, neuregulin, amphiregulin) in the bitch uterus during the estrus cycleen_US
dc.titleThe expression of epidermal growth factor receptors and their ligands (epidermal growth factor, neuregulin, amphiregulin) in the bitch uterus during the estrus cycle
dc.typeArticleen_US

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