Effects of Bemiparin Sodium Versus Dabigatran Etexilate After Anastomosis in Rat Carotid Arteries on the Development of Neointima and Thrombolytic Efficacy

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dc.contributor.authorOzturk, Pinar Aydin
dc.contributor.authorYilmaz, Tevfik
dc.contributor.authorOzturk, Unal
dc.date.accessioned2024-04-24T16:18:37Z
dc.date.available2024-04-24T16:18:37Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractBACKGROUND: Revascularization before infarct development after cerebral ischemia may affect morbidity. The success of revascularization can be less than expected because of spontaneous thrombosis or restenosis with intimal hyperplasia. The aim of this study was to compare dabigatran etexilate, a direct thrombin inhibitor, with bemiparin sodium, a second-generation low-molecular-weight heparin, after carotid artery anastomosis. METHODS: This study used 24 randomly selected Sprague-Dawley rats. The rats were separated into 3 equal groups: group 1 (control group); group 2 (dabigatran group), in which dabigatran 10 mg/kg was orally administered for 7 days; and group 3 (bemiparin group), in which bemiparin 250 IU/kg was subcutaneously administered for 7 days. The right-side carotid artery of rats was used for anastomosis and the left-side carotid artery was used for the control. The carotid artery was explored and transected. Anastomosis was applied using 10/0 polypropylene sutures. After 7 days of treatment, the right and left carotid arteries were removed. Lumen diameter, lumen area, tunica media thickness, edema, vessel wall injury, intimal hyperplasia, thrombus, and inflammation were evaluated in tissue biopsy specimens. RESULTS: Bemiparin used after anastomosis caused less thickening of tunica media and reduced intimal hyperplasia but did not decrease lumen diameter and area. Dabigatran increased edema and inflammation but did not prevent intimal hyperplasia. CONCLUSIONS: Bemiparin reduced intimal hyperplasia and prevented thrombosis angiogenesis, but dabigatran did not prevent intimal hyperplasia, and its anticoagulation effect was more than the antithrombotic effect.en_US
dc.description.sponsorshipTurkish Neurosurgical Societyen_US
dc.description.sponsorshipThe preparation of this article for publication was partly supported by the Turkish Neurosurgical Society.en_US
dc.identifier.doi10.1016/j.wneu.2019.02.139
dc.identifier.endpageE735en_US
dc.identifier.issn1878-8750
dc.identifier.issn1878-8769
dc.identifier.pmid30851469
dc.identifier.scopus2-s2.0-85063719721
dc.identifier.scopusqualityQ1
dc.identifier.startpageE731en_US
dc.identifier.urihttps://doi.org/10.1016/j.wneu.2019.02.139
dc.identifier.urihttps://hdl.handle.net/11468/16201
dc.identifier.volume126en_US
dc.identifier.wosWOS:000469222400090
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofWorld Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBemiparin Sodiumen_US
dc.subjectCarotid Artery Anastomosisen_US
dc.subjectDabigatran Etexilateen_US
dc.subjectNeointimaen_US
dc.subjectThrombosisen_US
dc.titleEffects of Bemiparin Sodium Versus Dabigatran Etexilate After Anastomosis in Rat Carotid Arteries on the Development of Neointima and Thrombolytic Efficacyen_US
dc.titleEffects of Bemiparin Sodium Versus Dabigatran Etexilate After Anastomosis in Rat Carotid Arteries on the Development of Neointima and Thrombolytic Efficacy
dc.typeArticleen_US

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