Clinical performance of ASAS Health Index in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis: real-world evidence from Multicenter Nationwide Registry

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dc.contributor.authorAkgul, Ozgur
dc.contributor.authorBodur, Hatice
dc.contributor.authorAtaman, Sebnem
dc.contributor.authorYurdakul, Fatma Gul
dc.contributor.authorCapkin, Erhan
dc.contributor.authorGurer, Gulcan
dc.contributor.authorSezer, Ilhan
dc.date.accessioned2024-04-24T16:00:06Z
dc.date.available2024-04-24T16:00:06Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe Assessment of SpondyloArthritis international Society Health Index (ASAS HI) is used as a new instrument in measuring the function, disability and health of patients with spondyloarthritis (SpA). However, the real-world evidence of ASAS HI is very limited. In the present study, our objective is to evaluate the psychometric properties and performance of ASAS HI in the real-world setting as well as comparing ASAS HI with the current instruments to assess the construct validity and determine the cut-off points in patients with both ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA). A total of 991 patients with axSpA who fulfilled either the ASAS classification criteria for axial SpA (axSpA) or the Modified New York Criteria (mNY) for AS were recruited from the Biologic and targeted Synthetic antirheumatic drugs Registry (BioStaR) SpA. The construct validity of ASAS HI against the Bath Ankylosing Spondylitis Disease Activities Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score-C-Reactive Protein (ASDAS-CRP) the Bath Ankylosing Spondylitis Functional index (BASFI) was performed. Using the receiver operating characteristic (ROC) curves analysis, the cut-off points were calculated. Of all the recruited patients, 851 (85.9%) were AS and 140 (14.1%) were nr-axSpA. The difference in the mean ASAS HI scores of the patients with AS and the ones with nr-axSpA were not statistically significant (6.12 +/- 4.29 and 6.42 +/- 4.86, respectively). The mean ASAS HI score was significantly higher in females and small city residents. The ASAS HI had a strong construct validity against ASDAS-CRP, BASDAI and BASFI. A cut-off point of <= 4 was determined to discriminate good and moderate, as well as >= 12 to discriminate moderate and poor health status. In conclusion, ASAS HI is a reliable instrument to evaluate health and functioning for both patients with AS and nr-axSpA in clinical practice.en_US
dc.description.sponsorshipTurkish League Against Rheumatism (TLAR) [06.23.2018-16]en_US
dc.description.sponsorshipThis study was funded Turkish League Against Rheumatism (TLAR) (Grant number 06.23.2018-16).en_US
dc.identifier.doi10.1007/s00296-020-04680-8
dc.identifier.endpage1801en_US
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.issue11en_US
dc.identifier.pmid32814986
dc.identifier.scopus2-s2.0-85089512036
dc.identifier.scopusqualityQ1
dc.identifier.startpage1793en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-020-04680-8
dc.identifier.urihttps://hdl.handle.net/11468/14372
dc.identifier.volume40en_US
dc.identifier.wosWOS:000561023200004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHealth Status Indexen_US
dc.subjectAnkylosing Spondylitisen_US
dc.subjectHealth-Related Quality Of Lifeen_US
dc.subjectFunctional Performanceen_US
dc.titleClinical performance of ASAS Health Index in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis: real-world evidence from Multicenter Nationwide Registryen_US
dc.titleClinical performance of ASAS Health Index in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis: real-world evidence from Multicenter Nationwide Registry
dc.typeArticleen_US

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