Protective effects of passiflora incarnata on ovarian ischemia/reperfusion damage in rats with ovarian torsion

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dc.contributor.authorArslan, Serkan
dc.contributor.authorAsir, Firat
dc.contributor.authorOzkorkmaz, Ebru Gokalp
dc.contributor.authorAzizoglu, Mustafa
dc.contributor.authorBasuguy, Erol
dc.contributor.authorOkur, Mehmet Hanifi
dc.contributor.authorOtcu, Serap Mutlu Ozcelik
dc.date.accessioned2024-04-24T17:17:58Z
dc.date.available2024-04-24T17:17:58Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractBACKGROUND: This study aimed to investigate whether Passiflora Incarnata (PI) has a protective effect against ischemia-reperfusion (IR)-induced oxidative and inflammatory ovarian damage. METHODS: The effects of PI on ovarian ischemia-reper fusion injury were investigated in female Wistar albino rats. The animals were randomly divided into three groups: Group 1 (sham), Group 2 (IR), and Group 3 (IR+PI). RESULTS: The mean levels of Malondialdehyde (MDA), Myeloperoxidase (MPO), and Total Oxidant Status (TOS) were higher in the IR group (p=0.025, p<0.001, and p=0.016, respectively). The Total Antioxidant Status (TAS) levels were lower in the IR group (p=0.005). Immunostaining revealed significant differences across the groups for Tumor necrosis factor-alpha (TNF-alpha): 13.84%, 49.51%, and 22.51% for Groups 1, 2, and 3, respectively (p<0.01). Bax: 10.53%, 46.74%, and 26.46% for Groups 1, 2, and 3, respectively (p<0.01). Annexin V: 12.24%, 44.86%, and 23.28% for Groups 1, 2, and 3, respectively (p<0.01). The mean scores for hemorrhage, inflammation, follicular degeneration, and congestion showed significant variations among the groups, all registering p<0.001. CONCLUSION: Passiflora Incarnata exhibited antioxidant, anti-inflammatory, and anti-apoptotic properties, promoting cell survival, histologically protecting ovarian tissue, and ameliorating IR injury by reducing oxidative stress.en_US
dc.description.sponsorshipDicle University scientific research project [TIP.21.024]en_US
dc.description.sponsorshipFinancial Disclosure: This study was conducted with the support of the Dicle University scientific research project (No: TIP.21.024) .en_US
dc.identifier.doi10.14744/tjtes.2023.52986
dc.identifier.endpage1350en_US
dc.identifier.issn1306-696X
dc.identifier.issn1307-7945
dc.identifier.issue12en_US
dc.identifier.pmid38073455
dc.identifier.scopus2-s2.0-85179360312
dc.identifier.scopusqualityQ3
dc.identifier.startpage1344en_US
dc.identifier.urihttps://doi.org/10.14744/tjtes.2023.52986
dc.identifier.urihttps://hdl.handle.net/11468/18498
dc.identifier.volume29en_US
dc.identifier.wosWOS:001125282700003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemia Reperfusionen_US
dc.subjectPassiflora Incarnataen_US
dc.subjectOvarian Torsionen_US
dc.subjectOvarian Damageen_US
dc.subjectOogenesisen_US
dc.titleProtective effects of passiflora incarnata on ovarian ischemia/reperfusion damage in rats with ovarian torsionen_US
dc.titleProtective effects of passiflora incarnata on ovarian ischemia/reperfusion damage in rats with ovarian torsion
dc.typeArticleen_US

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