HLA-DRB1 Alleles Distribution in Patients With Rheumatoid Arthritis in A Tertiary Center in the Southeastern Anatolia Region of Turkey

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dc.contributor.authorBatmaz, Ibrahim
dc.contributor.authorSariyildiz, Mustafa Akif
dc.contributor.authorDilek, Banu
dc.contributor.authorYildiz, Ismail
dc.contributor.authorNas, Kemal
dc.contributor.authorAyyildiz, Orhan
dc.contributor.authorCevik, Remzi
dc.date.accessioned2024-04-24T17:24:28Z
dc.date.available2024-04-24T17:24:28Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The HLA-DRB1 alleles play an important role in the genetic predisposition to rheumatoid arthritis (RA). The relationship between HLA-DRB1 and rheumatoid arthritis show differences according to various ethnic groups and geographical distributions. The aim of this study was to determine the distribution of HLA-DRB1 among the Turkish RA patient population in the Southeastern Anatolia Region. Materials and Methods: 96 patients diagnosed with RA and a control group consisting of 84 healthy individuals were enrolled in the study. The HLA-DRB1 type and subtypes were specified using the polymerase chain reaction with sequence specific primers (PCR-SSP) method. The between-group HLA-DRB1 type and certain subtype frequencies were compared. Results: The DRB1*10 alleles were found to be statistically significantly higher in patients with RA compared to the control group (p=0.001). However, the DRB1*07 and DRB1*11 alleles were statistically significantly lower in patients with RA (p<0.001 and p=0.02, respectively). In the RA patient group, the DRB1*0401, DRB1*0408 and DRB1*1001 subtypes were found to be statistically significantly higher (p=0.04, p=0.01, p=0.005, respectively), while the DRB1*0402, DRB1*0403 and DRB1*0701 subtypes were statistically significantly lower (p=0.01, p=0.02, p<0.001, respectively). Conclusion: This study has revealed the HLA-DRB1 distribution in the Southeastern Anatolia Region of Turkey. DRB1*10 type and DRB1*0401, DRB1*0408, DRB1*1001 subtypes were observed to be related with RA. DRB1*07, BRB1*11 types and DRB1 *0402, DRB1*0403, DRB1*0701 subtypes were accepted as protective alleles and subtypes.en_US
dc.identifier.doi10.4274/tftr.83446
dc.identifier.endpage127en_US
dc.identifier.issn1302-0234
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84879524066
dc.identifier.scopusqualityN/A
dc.identifier.startpage123en_US
dc.identifier.trdizinid160204
dc.identifier.urihttps://doi.org/10.4274/tftr.83446
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/160204
dc.identifier.urihttps://hdl.handle.net/11468/19688
dc.identifier.volume59en_US
dc.identifier.wosWOS:000321475100008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkiye Fiziksel Tip Ve Rehabilitasyon Dergisi-Turkish Journal of Physical Medicine and Rehabilitation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectHla-Drb1en_US
dc.subjectSubtypeen_US
dc.titleHLA-DRB1 Alleles Distribution in Patients With Rheumatoid Arthritis in A Tertiary Center in the Southeastern Anatolia Region of Turkeyen_US
dc.titleHLA-DRB1 Alleles Distribution in Patients With Rheumatoid Arthritis in A Tertiary Center in the Southeastern Anatolia Region of Turkey
dc.typeArticleen_US

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