Chemical fingerprints and bioactivities of 12 Anatolian Achillea L. species by LC-MS/ MS with chemometric approach: novel phytonutrients, natural food preservatives and chlorogenic acid sources

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dc.authorid0000-0002-4090-7227en_US
dc.authorid0000-0002-2193-8386en_US
dc.authorid0000-0002-0988-9462en_US
dc.authorid0000-0002-4377-0481en_US
dc.authorid0000-0002-2093-4949en_US
dc.authorid0000-0001-8932-4535en_US
dc.authorid0000-0002-0387-1819en_US
dc.authorid0000-0002-8006-2054en_US
dc.authorid0000-0001-5196-3892en_US
dc.authorid0000-0003-4163-9962en_US
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorErtaş, Abdulselam
dc.contributor.authorYener, İsmail
dc.contributor.authorTürkmenoğlu, Fatma Pınar
dc.contributor.authorÖlmez, Özge Tokul
dc.contributor.authorÖztürk, Mehmet
dc.contributor.authorAltun, Muhammed
dc.contributor.authorÇakır, Oğuz
dc.contributor.authorTarhan, Abbas
dc.contributor.authorBoğa, Mehmet
dc.date.accessioned2024-03-01T08:39:37Z
dc.date.available2024-03-01T08:39:37Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractThe objective of this study was to evaluate the biological activities and chemical fingerprint profiles of the extracts obtained from twelve Achillea L. species (A. lycaonica, A. biebersteinii (syn: A. arabica), A. kotschyi subsp. kotschyi, A. schischkinii, A. millefolium subsp. millefolium, A. sintenisii, A. setacea, A. teretifolia, A. wilhelmsii subsp. wilhelmsii (syn: A. santolinoides subsp. wilhelmsii), A. nobilis, A. goniocephala, A. spinulifolia). The antioxidant, enzyme inhibitory and cytotoxic effects were evaluated to investigate their bioactivity profiles. Furthermore, the total flavonoid and phenolic contents were determined and LC-MS/MS analysis was performed to reveal the phytochemical profile of the investigated extracts. A. kotschyi and A. nobilis species were detected to have very high antioxidant potential as well as high total phenolic content (260.00 ± 3.38 and 282.97 ± 3.14 μg of PEs mg extract–1, respectively). According to the LC-MS/ MS results, A. kotschyi and A. nobilis species were found to contain very high concentrations of chlorogenic acid (55812.20 and 46407 μg analyte g extract–1). Besides, the bioactivities and phenolic composition of these species were chemometrically analyzed using principal component analysis (PCA) and hierarchical clustering analysis (HCA) techniques. It has also been determined that Achillea species generally exhibit quite high cytotoxic activity against the HeLa cell line. The studied species showed high urease enzyme activities.en_US
dc.description.sponsorshipDicle University DUBAP ECZ.15.001en_US
dc.identifier.citationYılmaz, M. A., Ertaş, A., Yener, İ., Türkmenoğlu, F. P., Ölmez, Ö. T., Öztürk, M. ve diğerleri. (2022). Chemical fingerprints and bioactivities of 12 Anatolian Achillea L. species by LC-MS/ MS with chemometric approach: novel phytonutrients, natural food preservatives and chlorogenic acid sources. Turkish Journal of Botany, 46(5), 473-489.en_US
dc.identifier.doi10.55730/1300-008X.2723
dc.identifier.endpage489en_US
dc.identifier.issn1300-008X
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85138414564
dc.identifier.scopusqualityQ2
dc.identifier.startpage473en_US
dc.identifier.trdizinid1141742
dc.identifier.urihttps://journals.tubitak.gov.tr/botany/vol46/iss5/5/
dc.identifier.urihttps://hdl.handle.net/11468/13446
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1141742
dc.identifier.volume46en_US
dc.identifier.wosWOS:000889575400004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.institutionauthorErtaş, Abdulselam
dc.institutionauthorYener, İsmail
dc.institutionauthorÇakır, Oğuz
dc.institutionauthorTarhan, Abbas
dc.institutionauthorBoğa, Mehmet
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkish Journal of Botany
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAchilleaen_US
dc.subjectAntioxidanten_US
dc.subjectChemometric analysisen_US
dc.subjectCytotoxicityen_US
dc.subjectLC-MS/MSen_US
dc.subjectUrease and tyrosinaseen_US
dc.titleChemical fingerprints and bioactivities of 12 Anatolian Achillea L. species by LC-MS/ MS with chemometric approach: novel phytonutrients, natural food preservatives and chlorogenic acid sourcesen_US
dc.titleChemical fingerprints and bioactivities of 12 Anatolian Achillea L. species by LC-MS/ MS with chemometric approach: novel phytonutrients, natural food preservatives and chlorogenic acid sources
dc.typeArticleen_US

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