The evaluation of immune responses that occur after HBV infection and HBV vaccination in hemodialysis patients

Basit Öğe Kaydı
dc.contributor.authorKara, IH
dc.contributor.authorYilmaz, ME
dc.contributor.authorSuner, A
dc.contributor.authorKadiroglu, AK
dc.contributor.authorIsikoglu, B
dc.date.accessioned2024-04-24T16:18:36Z
dc.date.available2024-04-24T16:18:36Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe hepatitis B virus (HBV) vaccination never lose its importance; however, we did not get immune response with vaccination in some cases at the hemodialysis (HD) units. In this research, our aim was to evaluate antibody responses that constitute with natural ways and vaccination against HBV infection in chronic HD patients. In this retrospective cohort study (between 1999 February and 2001 December), 34 patients, 19 males and 15 females that were at the HD program, were enrolled. Patients were divided into two groups: group A, vaccination group (n = 15); and group B, anti-HBc IgG (+) cases (n = 19). We injected 40 mug of recombinant HBV vaccine into the deltoid muscle at 0, 11 2, and 6 months. The anti-HBs levels, over 10 mIU/mL, were accepted for enough immunization. In group A, after vaccination 12 of 15 (80%) patients had seroconversion but later, in five of 12 (33.3%) patients, HBs-antibody became negative and in seven of 12 (46.7%) patients the positivity of HBs-antibody continued. However, in group B, 16 of 19 (66.7%) immune patients who faced HBV infection. it was established that antibody response continued (P > 0.05). The patients in group A who had anti-HCV negativity and serum albumin levels greater than or equal to3.5 g/dL (7/0; P < 0.05) had too much antibody response against the vaccine. The difference of our research was that patients under 49 years old, patients who did not respond to HBV vaccine, were proportionally higher as compared to those from other researches. In conclusion, it was realized that the immune response of the HBV vaccine was low in the HD patients and it was affected by several factors such as gender, anti-HCV positivity and nutritional status. But, in spite of getting all universal precautions, still to face with new cases emphasizes the importance of the vaccination. (C) 2004 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.vaccine.2004.04.001
dc.identifier.endpage3967en_US
dc.identifier.issn0264-410X
dc.identifier.issn1873-2518
dc.identifier.issue29-30en_US
dc.identifier.pmid15364445
dc.identifier.scopus2-s2.0-4444235487
dc.identifier.scopusqualityQ1
dc.identifier.startpage3963en_US
dc.identifier.urihttps://doi.org/10.1016/j.vaccine.2004.04.001
dc.identifier.urihttps://hdl.handle.net/11468/16192
dc.identifier.volume22en_US
dc.identifier.wosWOS:000224154700020
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofVaccine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatitis Ben_US
dc.subjectVaccinationen_US
dc.subjectHemodialysisen_US
dc.subjectNutritional Statusen_US
dc.titleThe evaluation of immune responses that occur after HBV infection and HBV vaccination in hemodialysis patientsen_US
dc.titleThe evaluation of immune responses that occur after HBV infection and HBV vaccination in hemodialysis patients
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu