Biochemical, Histopathologic, and Genotoxic Effects of Ethanol Extract of Salvia hypargeia (Fisch. & Mey.) on Incisional and Excisional Wounded Diabetic Rats

Basit Öğe Kaydı
dc.contributor.authorOzay, Yusuf
dc.contributor.authorGuzel, Sevda
dc.contributor.authorOzkorkmaz, Ebru Gokalp
dc.contributor.authorKumas, Meltem
dc.contributor.authorUzun, Cosar
dc.contributor.authorYildirim, Zuhal
dc.contributor.authorCelik, Ayla
dc.date.accessioned2024-04-24T16:24:40Z
dc.date.available2024-04-24T16:24:40Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: Nonhealing wounds are a serious problem of diabetic patients. Salvia species are traditionally used for the treatment of wounds. The aim of the study was to investigate the effects of ointment prepared with ethanol extract obtained from the aerial parts of Salvia hypargeia, an endemic plant from Turkey, on diabetic rat incisional and excisional skin wounds. Materials and Methods: Male Wistar albino rats (n: 60) were divided into five groups. Diabetes was induced and two concentrations (0.5% and 1%) of the extract were used for ointments and applied on wounds for 7 and 14 days. Fito cream was chosen as a reference drug. Results: In excisional wounds, healing ratios of 0.5% (63.4% and 99.3%) and 1% (65.5% and 99.9%) S. hypargeia groups were higher compared to control (35.9% and 75.1%), and in incisional wounds, healing ratios of 0.5% (78.1% and 98.5%) and 1% (84.4% and 99.4%) S. hypargeia groups were higher compared to control (30.5% and 72.9%) (p < .01). Hydroxyproline (0.31 +/- 0.3 and 0.34 +/- 0.2) levels were lower and GSH (10.7 +/- 3.1 and 7.6 +/- 0.9) levels were higher in 0.5% and 1% S. hypargeia groups on the 14th day (p < .01). Histopathological results revealed re-epithelialization and formation of granulation tissue in all S. hypargeia groups. Genotoxicologic results indicated, GDI, DCP values, and MN frequency of 0.5% and 1% S. hypargeia groups did not reach to significant levels both on the 7 and 14 days. Conclusions: S. hypargeia may have a potential for therapeutic use in treatment and management of diabetic wounds with a successful topical application.en_US
dc.identifier.doi10.1080/08941939.2019.1590483
dc.identifier.endpage19en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue1en_US
dc.identifier.pmid30909758
dc.identifier.scopus2-s2.0-85063446046
dc.identifier.scopusqualityQ1
dc.identifier.startpage7en_US
dc.identifier.urihttps://doi.org/10.1080/08941939.2019.1590483
dc.identifier.urihttps://hdl.handle.net/11468/16811
dc.identifier.volume34en_US
dc.identifier.wosWOS:000605355300002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Investigative Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectWound Healingen_US
dc.subjectDiabetesen_US
dc.subjectSalvia Hypargeiaen_US
dc.subjectGshen_US
dc.subjectHistopathologyen_US
dc.subjectGenotoxic Effecten_US
dc.titleBiochemical, Histopathologic, and Genotoxic Effects of Ethanol Extract of Salvia hypargeia (Fisch. & Mey.) on Incisional and Excisional Wounded Diabetic Ratsen_US
dc.titleBiochemical, Histopathologic, and Genotoxic Effects of Ethanol Extract of Salvia hypargeia (Fisch. & Mey.) on Incisional and Excisional Wounded Diabetic Rats
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu