Lycium barbarum extract provides effective protection against paracetamol-induced acute hepatotoxicity in rats

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dc.contributor.authorGunduz, Ercan
dc.contributor.authorDursun, Recep
dc.contributor.authorZengin, Yilmaz
dc.contributor.authorIcer, Mustafa
dc.contributor.authorDurgun, Hasan Mansur
dc.contributor.authorKanici, Ayse
dc.contributor.authorKaplan, Ibrahim
dc.date.accessioned2024-04-24T17:37:37Z
dc.date.available2024-04-24T17:37:37Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of the present study was to investigate the hepatoprotective and antioxidant effects of Lycium barbarum (LB) extract against paracetamol-induced acute oxidative stress and hepatotoxicity in rats. The subjects were divided into 6 groups of 8 rats each. The rats in the LB group were administered a dose of 100 mg/kg LB extract dissolved in saline via the intraperitoneal route for 7 days. Subsequently, after last dose of LB, PCT was given in a single dose of 1 g/kg diluted in saline via the oral route. Twenty-four hours later, blood samples were drawn from all of the subjects for serum Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Total antioxidant status (TAS) and Total oxidant status (TOS) tests, and liver tissue samples were obtained for histopathological evaluation. The mean TAS level of the group that was subjected to PCT intoxication was significantly lower than those of the other groups. Additionally, the mean TOS, Oxidative stress index (OSI), ALT and AST values were significantly higher in this group. Though the mean TAS level in the PCT + LB group was significantly higher than that of the PCT group, the TOS, OSI, ALT, and AST levels were significantly lower. When the PCT + LB group and the PCT only group were compared in terms of liver damage during the histopathological evaluation, a statistically significant difference was observed in Grade I and Grade III damage (P = 0.013 and P = 0.038, respectively). We conclude that Lycium barbarum extract leads to a significant improvement in PCT-induced acute hepatotoxicity in terms of the histopathological results, serum oxidative stress parameters, and serum liver function marker enzymes.en_US
dc.identifier.endpage7905en_US
dc.identifier.issn1940-5901
dc.identifier.issue5en_US
dc.identifier.pmid26221346en_US
dc.identifier.scopus2-s2.0-84937010450en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage7898en_US
dc.identifier.urihttps://hdl.handle.net/11468/21076
dc.identifier.volume8en_US
dc.identifier.wosWOS:000359293200146en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLycium Barbarumen_US
dc.subjectParacetamol Intoxicationen_US
dc.subjectHepatic Damageen_US
dc.titleLycium barbarum extract provides effective protection against paracetamol-induced acute hepatotoxicity in ratsen_US
dc.typeArticleen_US

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