The effectiveness of automatic pupillometry as a screening method to detect diabetic autonomic neuropathy

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dc.contributor.authorErdem, Seyfettin
dc.contributor.authorKarahan, Mine
dc.contributor.authorAva, Sedat
dc.contributor.authorPekkolay, Zafer
dc.contributor.authorDemirtas, Atilim Armagan
dc.contributor.authorKeklikci, Ugur
dc.date.accessioned2024-04-24T16:02:12Z
dc.date.available2024-04-24T16:02:12Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose This study aimed to compare static and dynamic pupil responses of diabetic patients with and without nonproliferative diabetic retinopathy (DR) and normal healthy individuals under different lighting conditions via quantitative automated pupillometry. Methods Forty patients with DM with nonproliferative DR (group 1), 40 patients with DM without DR (group 2), and 40 healthy controls (group 3) underwent a complete ophthalmologic examination. Static pupillometry [scotopic pupil diameter (PD), mesopic PD, low photopic PD, and high photopic PD] and dynamic pupillometry (resting PD, contraction amplitude, latency, duration, velocity of contraction, dilatation latency, and duration and velocity at rest) were measured via automatic quantitative pupillometry. Results Analysis of variance revealed that scotopic PD [F(2, 117) = 6.42;p = 0.02], mesopic PD [F(2, 117) = 3.20;p = 0.04], and low photopic PD [F(2, 117) = 4.86;p = 0.009] were significantly different among the groups. Scotopic PD and low photopic PD were significantly lower in group 1 than in group 2 (p = 0.03 andp = 0.03, respectively). Meanwhile, the resting diameter, velocity of pupil contraction, and velocity of pupil dilatation were found to be significantly lower (p = 0.02,p = 0.01, andp = 0.008, respectively), and the duration of pupil contraction was significantly higher in group 1 than in group 3 (p = 0.03). Conclusion Both DM patients with and without nonproliferative DR exhibited pupillary involvement. Automated pupillometry may be an easily applicable, noninvasive screening option for reducing mortality and morbidity rates associated with diabetic autonomic neuropathy.en_US
dc.identifier.doi10.1007/s10792-020-01499-x
dc.identifier.endpage3134en_US
dc.identifier.issn0165-5701
dc.identifier.issn1573-2630
dc.identifier.issue11en_US
dc.identifier.pmid32623631
dc.identifier.scopus2-s2.0-85087448418
dc.identifier.scopusqualityQ2
dc.identifier.startpage3127en_US
dc.identifier.urihttps://doi.org/10.1007/s10792-020-01499-x
dc.identifier.urihttps://hdl.handle.net/11468/14683
dc.identifier.volume40en_US
dc.identifier.wosWOS:000545292700003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPupillometryen_US
dc.subjectDiabetic Retinopathyen_US
dc.subjectDiabetic Autonomic Neuropathyen_US
dc.titleThe effectiveness of automatic pupillometry as a screening method to detect diabetic autonomic neuropathyen_US
dc.titleThe effectiveness of automatic pupillometry as a screening method to detect diabetic autonomic neuropathy
dc.typeArticleen_US

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