BIOLOGICAL SURVEYING OF DIVERSE SCHIFF BASE COMPOUNDS: ANTIPROLIFERATIVE, ANTIRADICAL AND ENZYME INHIBITION ACTIVITY

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dc.contributor.authorPasa, Salih
dc.contributor.authorTuneg, Muhammed
dc.contributor.authorBoga, Mehmet
dc.date.accessioned2024-04-24T16:02:18Z
dc.date.available2024-04-24T16:02:18Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractSchiff base compounds (((1Z,1'Z)-(((ethane-1,2-diylbis(sulfanediyl))bis(2,1-phenylene))bis(azanylylidene)) bis(methanylylidene))bis(4,1-phenylene))diboronic acid (1), 1,1'-((1Z,1'Z)-([1,1'-biphenyl]-4,4'-diylbis(azanylylidene)) bis(methanylylidene))bis(naphthalen-2-ol) (2), 4,4'-((1Z, 1'Z)-([1,1'-biphenyl]-4,4'-diylbis(azanylylidene)) bis(methanylylidene))bis(2-methoxy phenol) (3), (N 4 Z, N 4'Z)-N 4, N 4'-bis(4-(dimethyl amino)benzylidene)-[1,1'-biphenyl]-4,4'-diamine (4), (E)-2-((2-hydroxybenzylidene)amino)terephthalic acid (5), and (E)-2-(((2-hydroxynaphthalen-1-yl)methylene)amino)terephthalic acid (6) have been synthesized. The structural identification was confirmed by spectroscopic techniques. The antiproliferative, antiradical, and enzyme activities were investigated in biological experiments. The obtained results showed that Schiff base compounds 1 - 6 exhibited meaningful features in various biological tests. A comparison of compound 1 (containing boron atom in the structure) to compounds 2 - 6 shows that the inclusion of boron in the Schiff base determines whether this would increase or not the efficiency in biological experiments. Hereby, compound 1 exhibited significantly different results in all applications.en_US
dc.identifier.doi10.1007/s11094-019-01997-y
dc.identifier.endpage311en_US
dc.identifier.issn0091-150X
dc.identifier.issn1573-9031
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85069495194
dc.identifier.scopusqualityQ4
dc.identifier.startpage302en_US
dc.identifier.urihttps://doi.org/10.1007/s11094-019-01997-y
dc.identifier.urihttps://hdl.handle.net/11468/14735
dc.identifier.volume53en_US
dc.identifier.wosWOS:000489093300004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPharmaceutical Chemistry Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSchiff Base Compoundsen_US
dc.subjectAntiproliferative Activityen_US
dc.subjectAntiradical Activityen_US
dc.subjectEnzyme Inhibitory Activityen_US
dc.titleBIOLOGICAL SURVEYING OF DIVERSE SCHIFF BASE COMPOUNDS: ANTIPROLIFERATIVE, ANTIRADICAL AND ENZYME INHIBITION ACTIVITYen_US
dc.titleBIOLOGICAL SURVEYING OF DIVERSE SCHIFF BASE COMPOUNDS: ANTIPROLIFERATIVE, ANTIRADICAL AND ENZYME INHIBITION ACTIVITY
dc.typeArticleen_US

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